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Diffusion collision
Secondary structures form first before folding
Nucleation condensation
Smooth transition from disordered to ordered state
Low contact order
nearby residues interact, generally faster
High contact order
Distant residues interact, generally slower
HSP-70
Shields hydrophobic portions of proteins from aggregation
GroEL-ES
Isolates unfolded proteins and use ATP to drive folding
Ions in RNA folding
Shields backbone charge, Specific concentration were folding occurs rapidly