Psychiatry Matrix

Psychosis

Impaired perception of reality through one or more of:

1. Hallucinations (sensory abnormalities w no stimuli)

2. Delusions (fixed false beliefs inconsistent to cultural/social norms)

3. Disorganised thinking, speech or behaviour

Primary Psychosis: results from psychiatric disorder (e.g. Schizophrenia)

Secondary Psychosis: results from general medical condition and/or the effect of a substance (inf., endocrine, neurological = stroke/tumour, autoimmune = SLE, B12 def.)

Psychotic Disorder: disease/condition producing psychosis

Schizophrenia Dx (R1)

Pos, Neg and Cognitive signs/sx of Psychosis persist for >6m, PLUS Social and Functional decline:

• A) 2+ for >1m of: 1) Delusions, 2) Hallucinations, 3) Disorganised Speech, PLUS 4) Grossly Disorganised or Catatonic Behaviour, 5) Neg. Sx (dec. emotions)

• B) Severe impact on function ability (work, care etc)

• C) Duration persists >6m (Criteria A = >1m)

• D) Ruled out Schizoaffective, Depressive or Bipolar

• E) Ruled out attribution to effects of substances

RF: Genetics, Substances, Environmental/Psychosocial

• Men = 18-25

• Women = 25-35 (menarch) + >40 (menopause)

  • Late Onset Schizophrenia: >40-60, W>M, fewer neg. sx

Screening Tools:

• PANSS (Pos + Neg Sx Scale)

• BPRS (Bried Psychiatric Rating Scale)

• Screen for organic cause (CRP, TSH, Urine)

MSE: A/B: poor, disorganised; M: abnorm; S: abnorm, delusions; C: low/distracted; R: __; I: impaired; J: impaired; P: hallucinations

Substance‑Induced Psychosis (R1)

Psychosis must be a direct consequence of substance USE or WITHDRAWAL

Sx development is related to the time the substance was last ingested, and sx duration is usually brief

Causes:

1. Recreational: Alcohol, Hallucinogens, Cocaine, Cannabis, Amphetamines

2. Medications: Analgesics (Opioids), Antihistamines, Sedatives/Hypnotics, Antidepressants (SSRIs), Benzo, Antiparkinsons (dopaminergics), Corticosteroids

Substance-Induced Psychotic Disorder: when sx outlast expected intoxication/withdrawal duration (however, >4wks indicates other psychotic disorders)

Schizoaffective Disorder (R2)

Mix of Schizophrenia and Bipolar Disorder (Psychosis AND Mania) for >2wks

A) Period of either: 1) Major Depressive Eps, 2) Manic Ep, 3) Mixed Ep with Schizophrenia sx of Criteria A

B) Delusions or Hallucinations for >2wks in SAME period of illness as Criteria A WITHOUT Mood Sx

C) Sx of Mood Ep. for majority of illness period

D) Ruled out attribution to effects of substances

Schizophreniform Disorder (R2)

Schizophrenic sx for a shorter duration of 1-6m

2/3 Pts develop Schizophrenia or Schizoaffective dis.

Criteria:

A) 2+ for >1m of: 1) Delusions, 2) Hallucinations, 3) Disorganised Speech, PLUS 4) Grossly Disorganised or Catatonic Behaviour, 5) Neg. Sx (dec. emotions)

B) Severe impact on function ability (work, care etc)

C) Duration persists 1-6m

D) Ruled out Schizoaffective, Depressive or Bipolar

E) Ruled out attribution to effects of substances

Delusional Disorder (R3)

At least 1 delusion

No other prominent psychotic sx (hallucinations, disorganised speech, negative sx)

A) Nonbizarre delusions >1m (i.e., involving situations that occur in real life, such as being followed, poisoned, infected, loved at a distance, or deceived by spouse or lover, or having a disease)

B) Criterion A for Schizophrenia has never been met

C) Functioning/Behaviour not impaired apart from the ramifications of the particular delusion

D) Any assoc. Mood Eps. have been comparatively brief

E) Ruled out attribution to effects of substances

Nonbizzare Del: can be true +/or consistent w cultural/social norms

Bizzarre Del: canNOT be true +/or inconsistent w cultural/social norms

Grandiose Del: insists special powers/importance

Brief Psychotic Disorder (R3)

A) Presence of >1 of: 1) Delusions, 2) Hallucinations, 3) Disorganised Speech, 4) Disorganised/Catatonic Behaviour

B) Duration is >1d BUT <1m with FULL functional return

C) Have Ruled out Mood Disorder With Psychotic Features, Schizoaffective Disorder, Schizophrenia or Substance Effects

RF: Stressful life event

Psychotic Disorders Mx

Screen for: past Dx of Psychosis, onset (sudden = 2°), head trauma, meds/drug hx, PMHx (Cushings, autoim, THYROID DISEASE!), Life Stressors, FHx

Ix: TFT, BMP, CBC, LFTs, ESR, ANA, Vit B12, Thiamine, HIV/Syphilis, Preg., Urine Tox, MRI/CT Head, EEG

Mx:

Psychosocial Intervs: better for neg/cog sx (CBTp)

Antipsychotic Medications:

*1st Line = Aripiprazole, Risperidone, Olanzapine, Quetiapine (SGAs); Haloperidol, Chlorpromazine (FGAs)

*Tx Resistant = Clozapine following failure of TWO different antipsychotics each for ≥ 6wks (requires CBC for neutropenia risk monitoring, AEs = constipation, myocard.)

1st Gens (FGA) = dopamine receptors (muscular sx)

2nd Gens (SGA) = dopamine + serotonin (metabolic sx => monitor lipids, weight and BGLs) - SGA > FGA

Ari = young pts/ASD, acathesia (restlessness)

Risp = young pts/ASD, hyperprolactinaemia/galactorrhea

Olanz = weight gain/metabolic issues (O = wide)

Quet = sedating (Quet = Quiet)

Halo = Dystonia + NMS risk, EPSEs, hyperprolact., QT risk

Chlor = anticholinergic effects, photosens., HYPOtension

Bipolar I Disorder (R1)

Manic episodes >1wk OR causing hospitalisation NOT due to an organic/substance related cause

RF = FHx!!!, Age (18-30)

VERY High Risk of Suicide - Do Risk Assessment

Manic Eps = distinct periods of abnormally and persistently elevated, expansive, or irritable mood, PLUS abnormally and persistently increased energy or activity

3+ sx of DIGFAST:

1) Distractibility: attention draws easily to irrelevant stimuli

2) Impulsivity/High-Risk Behavior: excessive activities with painful consequences (e.g., buying sprees, sexual indiscretions)

3) Grandiosity: Inflated self-esteem

4) Flight of Ideas/Racing Thoughts

5) Activity Increase/Goal-Directed Activity: increased energy at work, school, or socially, +/- psychomotor agitation

6) Sleep Def/Decreased Sleep: feeling rested after only a few hours

7) Talkativeness: pressured speec

Bipolar II Disorder (R2)

Hypomanic (low levels of mania) >4d

PLUS

Major Depressive episode >2wks

WITHOUT

Full manic episode/Major functional impairment

Drug‑Induced Mania (R3)

Mania distinct from a primary (non-substance-induced) bipolar disorder

Sx preceding the substance use, or persisting for a SIGNIFICANT TIME (>1m) after cessation

Substance Abuse: Usually cocaine and amphetamines, can be caused by ETOH, cannabis, opioids etc

Medications: antiparkinsonian drugs, corticosteroids, thyroxine

Suspicious for pts with mania age >35yrs

Cyclothymic Disorder (R3)

Episodes of hypomania and depression that:

1) Do not meet the full DSM‑5 diagnostic criteria for hypomania or major depressive disorder

2) Present at least half the time during a 2‑year period with ≤ 2 months of symptom remission

Bipolar and Related Disorders Mx

Consider ceasing antidepressants which can cause mania, should only use (SSRIs preferred) WITH Mood Stabilisers

Address triggers (sleep dep,. substance use)

Electroconvulsive Therapy (ECT) for sev./med intolerant

Medications: Combination Therapy (1 + 2) for Mod-Sev.

1) Mood Stabilisers: Lithium (1st), Valproate (Avoid in Preg.), Lamotrigine (ONLY for depressive eps/depres-prominent)*

2) Antipsychotics: SGAs preferred (Aripip, Risp, Olanz, Quet)

3) Benzodiazepines: Lorazepam (for SHORT TERM and SEVERE: agitation, insomnia, behavioural disturbances)

Bipolar Depression: Quetiapine monotherapy, Lithium, Lamotrigine (more for prevention, slower onset), Lurasidone (often with lithium or valproate)

*Do NOT give high dose of Lamotrigine or Lam + Val due to high risk of SJS/TENS (skin burns)

Major Depressive Disorder (R1)

>5 sx from the 9 Sx Domains for >2wks including at least one of:

1) Depressed mood

2) Loss of interest or pleasure (anhedonia)

PLUS Functional Impact/Distress (Social, Occup. etc)

NOT attributable to a substance or medical condition

NO Hx of Mania/Hypomania Eps (rule out Bipolar)

The 9 symptom domains:

1) Depressed mood most of the day, nearly every day

2) Markedly reduced interest or pleasure in most activities

3) Significant weight loss or gain, or appetite change

4) Insomnia or hypersomnia

5) Psychomotor agitation or retardation (observable by others)

6) Fatigue or loss of energy

7) Feel worthless or excessive/inappropriate guilt

8) Reduced concentration or indecisiveness

9) Recurrent thoughts of death, suicidal ideation, or suicide attempt

Substance‑Induced Depressive Disorder (R3)

Clinically significant depressive syndrome that:

1) Develops during or soon after substance intoxication, withdrawal, or medication exposure

2) Is attributable to that substance

3) Is not better explained by a primary depressive disorder

Substance/Med is capable of causing depressive sx

E.g. ETOH, Opioids, Sedatives/Hypnotics, Stimulant Withdrawal, Other Prescribed Meds

Persistent Depressive Disorder/Dysthymia (R3)

Chronic depressive condition characterised by:

1) Depressed mood for most days for >2yrs (>1yr for children/adolescents: will be irritable > sad)

2) >2 additional depressive sx

3) No prolonged symptom‑free periods (not >2m)

4) No history of mania or hypomania

Disruptive Mood Dysregulation Disorder/DMDD (R3)

Childhood disorder characterised by severe, chronic irritability, rather than episodic mood elevation

A) Frequent Severe Temper Outbursts (Verbal/Behav)

B) Persistent Irritable Mood/Anger (close to 24/7)

C) Frequency of Temper Outbursts >3 times/wk

D) Duration >12m, No sx-free period >3m (consec.)

E) Sx in >2 settings (sev. in >1): home, school, w peers

F) Dx age only bw 6-18yrs (onset sx before 10yrs)

G) Exclusion of Mania/Not Better Explained by Another Dx/Disorder or Substances/Med. Condition

Disruptive mood dysregulation disorder is a childhood condition characterised by severe, recurrent temper outbursts and persistent irritability lasting at least 12 months across multiple settings, with onset before age 10 and no history of manic or hypomanic episodes

Depressive/Mood Disorders Mx

Antidepressants:

1) SSRIs

2) SNRIs/Other ()

SSRIs:

Sertriline: all-rounder, 1st line, min AEs,

Fluoxetine: min AEs, more activating than Sert (gives energy)

Generalised Anxiety Disorder/GAD (R1)

>6m of Excessive Worry about Everyday Issues that:

1) Is disproportionate to any inherent risk

2) Causes distress or impairment

3) Is hard to control

>3 sx are present most of the time:

1) Restlessness or nervousness

2) Being easily fatigued

3) Poor concentration

4) Irritability

5) Muscle tension

6) Sleep disturbance

Panic Disorder (R2)

Recurring unexpected panic attacks over >1m

Patient remains persistently concerned/anxious about having another attack

Not Due to Subs/Med Conds/Other Mental Disorders

At least one panic attack is followed by ≥1 month of one or both of:

1) Persistent concern/worry about panic attacks or their consequences

2) Persistent concern or worry about

Panic Attacks: sudden onset of intense physical and cognitive symptoms of anxiety that may be triggered by specific cues or occur unexpectedly

Agoraphobia (R2)

A = Marked fear or anxiety for >6m regarding >2 of:

1) Using public transport (e.g. buses, trains, planes)

2) Being in open spaces (e.g. car parks, marketplaces)

3) Being in enclosed spaces (e.g. shops, cinemas)

4) Standing in line or being in a crowd

5) Being outside the home alone

B = Reason for fear is hard to escape/get help

C = Situations are avoided/endured w distress/need a companion due to provoking fear/anxiety

D = Fear is out of proportion to posed danger

E = Functional Impairment (social, occupational etc)

F = Not better explained by another disorder

Can be diagnosed with/without panic disorder

Specific Phobias (R2)

intense fears of SPECIFIC OBJECTS or SITUATIONS persistent for >6m that are triggered upon actual or anticipated exposure to phobic stimuli

Exposure to the phobic stimulus almost always provokes immediate fear or anxiety

Situations w phobic cues are avoided/endured with intense anxiety

Excessive fears can cause functional impairments or lifestyle disruptions and is out of proportion

Mx = Exposure Therapy/CBT, Benzos for infrequent sx

Anxiety Disorders Mx

Obsessive‑Compulsive Disorder (R1)

Presence of one or both of:

A) Obsessions: recurrent/persistent thoughts, urges or images that are intrusive/unwanted causing anxiety or distress (attempt to ignore/neutralise)

B) Compulsions: repetitive behaviours/mental acts in response to an obsession aiming to prevent/reduce anxiety or distress that pt feels driven to perform

Obsessions/Compulsions are Time Consuming (>1hr/d) or cause distress/impaired functioning

Not better explained by sub./condition/disorder

Mx = Pharm + CBT/ERP

Body Dysmorphic Disorder/BDD (R3)

A) Preoccupation with appearance: >1 perceived flaws or defects not observable/apparent to others

B) Repetitive Behaviours/Mental Acts (skin pick etc)

C) Clinically Significant Distress or Impairment

D) Not Better Explained by an Eating Disorder

Muscle Dysmorphia Specifier: Preoccupation that the body is too small or insufficiently muscular (M > F)

Mx = Pharm + ERP

Hoarding Disorder (R3)

A) Persistent Difficulty Discarding Possessions (value regardless, perceived need to save items)

B) Accumulation/Clutter due to difficulty discarding

C) Clinically Significant Distress or Impairment

D) Not better explained by sub./condition/disorder

Mx = CBT

Trichotillomania (R3)

A) Recurrent pulling out of hair, resulting in hair loss

B) Repeated Attempts to Stop

C) Clinically Significant Distress or Impairment

D) Not better explained by sub./condition/disorder

Mx = HRT

Excoriation Disorder (R3)

A) Recurrent skin picking, resulting in skin lesions

B) Repeated Attempts to Stop

C) Clinically Significant Distress or Impairment

D) Not better explained by sub./condition/disorder

Mx = Pharm + HRT

Obsessive‑Compulsive & Related Disorders Mx

Non-Pharm: CBT/ERP!/HRT

Pharm: SSRIs +/- Tricyclic Antis (Clomipramine)

Do not give citalopram to BDD

ERP (Exp + Response Prev): systematic exposure to feared stimuli while preventing compulsive behaviours to reduce anxiety

HRT (Habit Revers Train): identifies triggers and substitutes behaviors

Clomipramine: Seratonin-Specific, Less Tolerated than SSRIs

Post Traumatic Stress Disorder - PTSD (R1)

All 4 Groups of sx for >1m following exp. to trauma:

1) Intrusion symptoms ≥1 (memories, reactions, etc)

2) Avoidance ≥1 (memories, reminders/places etc)

3) Negative alterations in cognition and mood ≥2 (e.g. inhibited memory, blame, neg. beliefs/emotions)

4) Alterations in arousal and reactivity ≥2 (irritable, reckless, sleep disturbance, dec. concentration etc)

Sx cause functional impairment

Trauma = actual/threatened death, serious injury, or sexual violence through direct experience, witnessing, of learning of from close family/friend

Acute Stress Disorder (R2)

Sx for 3d-1m, within 4wks following exp. to trauma

1) Intrusion symptoms ≥1 (memories, reactions, etc)

2) Avoidance ≥1 (memories, reminders/places etc)

3) Negative alterations in cognition and mood ≥2 (e.g. inhibited memory, blame, neg. beliefs/emotions)

4) Alterations in arousal and reactivity ≥2 (irritable, reckless, sleep disturbance, dec. concentration etc)

Sx cause functional impairment

Adjustment Disorders (R2)

A) Emotional or behavioural sx within 3m of an identifiable stressor

B) Causes disproportionate distress or functional impairment

C) Not better explained by sub./condition/disorder

D) Resolves within 6m of the stressor ending

Trauma & Stress‑Related Disorders Mx

Mild/Mod Sx <3m: active monitoring, supportive

Severe <3m or Sx ≥3: Psych Therapy, Pharm

Trauma-focused cognitive behavioural therapy (TFCBT)

Eye movement desensitisation and reprocessing (EMDR)

Pharm: 1st = SSRIs, SNRIs (Venlafaxine, monitor BP), Mirtazapine (for insomnia), Prazosin (nightmares)

Dissociative Identity Disorder (R3)

A) Presence of >2 distinct identities (alters) that control a person's behavior, often caused by severe, chronic childhood trauma

B) Causes recurrent amnesia/gaps in recall

C) Clinically Significant Distress or Impairment

D) Not a Normal Cultural or Religious Practice

E) Not Due to Substances or Medical Conditions

Dissociative Amnesia (R3)

A) Inability to Recall Important Information, usually following trauma/stress and is inconsistent with ordinary forgetting

B) Clinically Significant Distress or Impairment

C) Not better explained by sub./condition/disorder

Depersonalisation/Derealisation Disorder (R3)

A) Persistent or Recurrent Experiences of one or Both of: 1) Depersonalisation (robotic), 2) Derealisation (detachment)

B) Reality Testing Remains Intact

C) Clinically Significant Distress or Impairment

D) Not better explained by sub./condition/disorder

Dissociative Disorder Mx

Psychotherapy, CBT

Psychoeducation

Borderline Personality Disorder/BPD (R1) - Cluster B

Personality and Emotional Regulation Disorder

Pervasive pattern of instability in affect, self‑image, and interpersonal relationships with marked impulsivity

>5 of IMPULSIVE:

1) Impulsivity in >2 potentially self‑damaging areas (e.g. sex, money, substances)

2) Moodiness

3) Paranoia: Transient, stress‑related paranoid ideation or severe dissociative symptoms

4) Unstable self image/Identity disturbance

5) Labile intensive relationships: Unstable and intense interpersonal relationships

6) Suicidal: Recurrent suicidal behaviour, gestures, threats, or self‑mutilating behaviour

7) Inappropriate/intense anger or difficulty controlling anger

8) Vulnerability or abandonment

9) Emptiness: Chronic feelings of emptiness

Mood fluctuations over the course of the DAY/short periods (Bipolar = over longer periods/episodic/wks)

Feel unsafe in relationships, threat of abandonment

RF = genetics, trauma, difficult relationships

Usually emerges in adolescence or early adulthood

Is REVERSIBLE with Mx

Antisocial Personality Disorder (R2) - Cluster B

Pervasive pattern of disregard for and violation of the rights of others

Sx occur since age 15yrs, with dx made in adulthood

A) Pervasive Pattern of Antisocial Behaviour (failure to conform, impulsive, deceitful, reckless)

B) Age Requirement >18rs (must be an adult)

C) Evidence of Conduct Disorder Before Age 15

D) Exclusion Criteria: Antisocial behaviour does not occur exclusively during schizo/bipolar/mania

Narcissistic Personality Disorder (R2) - Cluster B

Pervasive pattern of grandiosity, need for admiration, and lack of empathy, beginning by early adulthood

>5 of:

1) Grandiose sense of self‑importance

2) Preoccupation with fantasies (success, power etc)

3) Belief of being "special" and unique

4) Requires excessive admiration

5) Sense of entitlement

6) Interpersonally exploitative behaviour

7) Lack of empathy

8) Envy of others/belief others envy them

9) Arrogant, haughty behaviours or attitudes

Traits are Pervasive, Inflexible, Maladaptive

Not better explained by Mood disorders (e.g. mania), Substance use or Cultural/Occupational norms

Obsessive‑Compulsive Personality Disorder (R2) - Cluster C

Pervasive pattern of preoccupation with orderliness, perfectionism, and control

>4 of:

1) Preoccupation with details, rules, lists, order, organisation, or schedules

2) Perfectionism that interferes with task completion

3) Excessive devotion to work and productivity (not explained by financial necessity)

4) Overconscientiousness, scrupulousness, and inflexibility about morality, ethics, or values

5) Inability to discard worn‑out/worthless objects, even with no sentimental value

6) Reluctance to delegate tasks or work with others

7) Miserly spending style toward self/others (hoards)

8) Rigidity and Stubbornness

Diagnosed in adulthood

Personality trait rather than anxiety disorder (OCD)

Limited insight but usually no obsession/compulsions

Paranoid Personality Disorder (R3) - Cluster A

Pervasive pattern of distrust and suspicion of others

>4 of:

1) Suspects, without sufficient basis, that others are exploiting, harming, or deceiving them

2) Preoccupied with unjustified doubts about the loyalty or trustworthiness of friends or associates

3) Reluctant to confide in others

4) Reads hidden demeaning or threatening meanings into benign remarks or events

5) Persistently bears grudges (unforgiving of insults, injuries, slights)

6) Perceives attacks on character or reputation

7) Recurrent suspicions, without justification, of the fidelity of a spouse/sexual partner

Disturbance does not occur exclusively during: Schizophrenia, Bipolar/Mania, Other Psych Disorder

Schizoid Personality Disorder (R3) - Cluster A

Pervasive pattern of detachment from social relationships and a restricted range of emotional expression

> 4 of:

1) Neither desires nor enjoys close relationships, including being part of a family

2) Almost always chooses solitary activities

3) Min-No interest in sexual experiences with another

4) Takes pleasure in few/any activities

5) Lacks close friends/confidants, except 1st‑degree relatives

6) Appears indifferent to praise/criticism from others

7) Shows emotional coldness, detachment, or flattened affectivity

Disturbance does not occur exclusively during: Schizophrenia, Bipolar/Mania, Other Psych Disorder

NOT Attributable to ASD or Medical/Neuro Condition

Schizotypal Personality Disorder (R3) - Cluster A

Pervasive pattern of social and interpersonal deficits, marked by: acute discomfort with close relationships, cognitive/perceptual distortions, eccentric behaviour

> 5 of:

1) Ideas of reference (exclude fixed delusions)

2) Odd beliefs or magical thinking (e.g. superstitions, clairvoyance, belief in special powers)

3) Unusual perceptual exp. (incl. bodily illusions)

4) Odd thinking/speech (e.g. vague, circumstantial, metaphorical, or over‑elaborate)

5) Suspiciousness or paranoid ideation

6) Inappropriate or constricted affect

7) Behaviour/appearance that is odd, eccentric, or peculiar

8) Lacks close friends/confidants, except 1st‑degree relatives

9) Excessive social anxiety (familiarity does not dec.)

Disturbance does not occur exclusively during: Schizophrenia, Bipolar/Mania, Other Psych Disorder

NOT Attributable to ASD or Medical/Neuro Condition

Histrionic Personality Disorder (R3) - Cluster B

Pervasive pattern of excessive emotionality and attention‑seeking

> 5 of:

1) Uncomfortable when not the centre of attention

2) Interactive behaviour with others is often inappropriate, sexually seductive or provocative

3) Rapidly shifting/shallow expression of emotions

4) Consistently uses physical appearance to draw attention to self

5) Style of speech is excessively impressionistic and lacking in detail

6) Self‑dramatisation, theatricality, and exaggerated expression of emotion

7) Suggestibility: easily influenced by others or circumstances

8) Considers relationships to be more intimate than they actually are

Traits must not occur exclusively during: Mood Disorders (e.g. mania) or Substance Intoxication

Must be pervasive and enduring, not situational

Avoidant Personality Disorder (R3) - Cluster C

Pervasive pattern of social inhibition, feelings of inadequacy, and hypersensitivity to negative evaluation

> 4 of:

1) Avoids occupational activities that involve significant interpersonal contact (due to fears of criticism, disapproval, or rejection)

2) Unwilling to get involved with people

3) Shows restraint within intimate relationships

4) Preoccupied with being criticised or rejected in social situations

5) Inhibited in new interpersonal situations

6) Views self as socially inept, personally unappealing, or inferior to others

7) Unusually reluctant to take personal risks/engage in new activities

Must not be better explained by: Social anxiety disorder alone, ASD, Mood disorders

Must be pervasive and enduring, not situational

Dependent Personality Disorder (R3) - Cluster C

Pervasive and excessive need to be taken care of, leading to submissive and clinging behaviour and fears of separation

> 5 of:

1) Difficulty making everyday decisions without excessive advice and reassurance from others

2) Needs others to assume responsibility

3) Difficulty expressing disagreement

4) Difficulty initiating projects or doing things independently

5) Goes to excessive lengths to obtain nurturance and support

6) Feels uncomfortable or helpless when alone

7) Urgently seeks another relationship when one ends

8) Unrealistic preoccupation with fears of being left to take care of themselves

Traits must not be better explained by: Major depressive dis, Anxiety dis, Medical illness

Must be pervasive and enduring, not situational

Personality Disorder Mx

Psychotherapy = 1st line!

Create Crisis/Risk Management Plan

Adjunct Pharmacotherapy for Comorbidites (SSRIs for Depression/Anxiety etc)

Cluster A: odd or eccentric

Cluster B: dramatic, emotional and erratic

Cluster C: anxious or fearful

Anorexia Nervosa (R1)

Restriction of caloric intake relative to requirements leading to:

1) Low body weight for age, height, gender and developmental status

2) An intense fear of gaining weight

3) A body image disturbance/Overvaluation of weight or shape as an expression of self-worth

Two Subtypes:

1) Restrictive: no binging, limiting food intake, compulsive exercise

2) Binge Eating and Purging: recurrent episodes of binge eating (uncontrolled overeating) and purging (eg self-induced vomiting, laxative or diuretic misuse)

Often have medical and psychological comorbidities (eg osteopenia, pancreatitis, depression, anxiety)

Hospitalise when BMI <15, BP <80 systolic, dec. vitals

Life-threatening Weight Loss: BMI <15 in adults, <75% of median BMI for age + sex in children/adolescents

Precipitous Weight Loss: LOW >1kg for two consecutive weeks

Bulimia Nervosa (R1)

Severe preoccupation about weight and body shape

1) Recurrent episodes of binge eating, loss of control over eating

2) Compensatory mechanisms to prevent weight gain (self-induced vomiting, fasting, excessive exercise)

3) Body weight in the adequate to obese range

Binge eating and compensatory behaviours occur at least once weekly for >3m

RF: women in 20s/30s, trauma hx

Common Signs: Parotid Hypertrophy, Tooth Erosion

Feeding & Eating Disorder Mx

CBT/Psychotherapy

Nutritional replenishment/Re-feeding

Dietitian Referral

Pharm:

AN: No evidence for pharmacological mx

BN: SSRIs (1st = Fluoxetine, Citalopram, Fluvoxamine, Sertraline) - for young adults

Mx comorbidities (depression etc) and beware of pregnancy

Alzheimer's Disease (R1)

Chronic, progressive neurodegenerative disorder with global, non-reversible impairment in cerebral functioning

A) Neurocognitive Decline + Memory Impairment

B) Insidious onset with gradual, steady decline

Deteriorating course over up to 8-10yrs

Brain lesions: neurofibrillary tangles, senile plaques, neuronal loss, brain atrophy, acetylcholine synth defects

Most common dementia but can coexist with others

RF = Age, FHx, Genetics, Down's Syn., Hyperlipidaemia, Cerebrovascular disease, Drugs, Unfinished School

Vascular Dementia (R1)

Chronic progressive impairment of cognitive function caused by loss of brain parenchyma

• Predominantly from cerebrovascular causes (infarction, haemorrhage, small-vessel changes)

• Damage to grey and white matter

Signs:

• Loss of Executive Functions (planning etc) > Memory

• Motor and mood changes are often seen early

RF: age >60, obesity, HTN, smoking, DM

IX: MRI Brain, Ix causes of cog decline (UEC, BGL, B12)

Treat early and aggressively to prevent further cerebrovascular disease/address causes

Frontotemporal Dementia (R2)

Neurodegenerative Dementia causing disruption in personality and social conduct ± primary language disorder (2nd most common after AD)

Sx: Parkinsonism (50% of pts), Language Impairment, Personality/Social Behaviour Decline, Altered Eating Habits, Inattentiveness, Impulsivity

Note: does not usually present w memory loss

RF: Age 45-65 (mid-life), FHx, Genetics

Lewy Body Dementia (R2)

Neurodegenerative disorder with Lewy Bodies characterised by:

1. Parkinsonism (Bradykinesia, Tremor, Rigidity)

2. Progressive cognitive decline (with fluctuations)

3. Prominent executive dysfunction

4. Behavioural and sleep disturbances (REM disorder)

5. Visuospatial impairment

Ix: Pathology shows presence of Lewy Bodies (Autopsy?), CT/MRI Head, Screening

Mx:

• Behavioural = Cholinesterase Inhibitors (Donepezil and Rivastigmine are best for behavioural sx without motor sx exacerbation)

• REM Disorder = Clonazepam/Melatonin

• Motor Sx = Levodopa/Carbidopa

Lewy Bodies: toxic clumps formed by damaged alpha-synuclein proteins folding into irregular shapes (linked to progressive dopamine loss in the brain)

Dementia due to Parkinson's Disease (R3)

Significant cognitive decline after >1yr of motor sx due to Parkinson’s Disease

Often overlap with Lewy Body Dementia (cognitive decline and motor sx begin and progress together)

Dementia due to Prion Disease (R3)

Very rapidly progressive fatal dementias due to prions

Disease is spontaneous, genetic or acquired

Sx: Behavioural/psychiatric changes, memory impairment, visual disturbances, myoclonus, ataxia, language/hearing issues, movement dysfunction

RF: genetics, prion-contaminated surgical instruments, blood products/transfusions, UK Beef 1980-1996

Ix: pathology = definitive, MRI B

No cure - only palliative management (mortality = 1yr)

Dementia due to Huntington's Disease (R3)

Autosomal dominant slow-progressing neurodegenerative disorder often presenting mid-life

Sx: chorea, incoordination, cognitive decline, personality changes, psychiatric sx (resulting in immobility, mutism, and inanition)

Prognosis: 20yrs from dx

RF: genetics/FHx (pre-test genetic counselling/testing is recommended)

Dementia due to HIV (R3)

HIV-Associated Neurocognitive Disorder (HAND)

Rare neurodegenerative disorder resulting from HIV infection (virus attacks brain cells causing inflammation and damage)

• Does not directly infect neurons but indirectly causes cognitive damage → subcortical dementia

More common in the later stages of HIV infection (7% of pts), but rare due to antiviral treatments (ART)

Severity levels:

1. Asymptomatic Neurocognitive Impairment (ANI)

2. Mild Neurocognitive Disorder (MND)

3. HIV‑Associated Dementia (HAD) = severe form

Signs and Sx:

• Cognitive Features

  • Bradyphrenia (slowed thinking), Impaired attention/concentration, Executive dysfunction (planning/decisions), Memory retrieval problems (rather than storage)

• Motor Features

  • Gait instability, Poor coordination, Slowed movements, Tremor

• Behavioral / Psychiatric Features

  • Apathy, Depression, Irritability, Social withdrawal

Unlike Alzheimer’s disease, language and visuospatial skills are preserved

Neurocognitive Disorder Mx (Dementia)

• Supportive: Exercise/Physical Activity, Memory Aids, CBT

• End of life care

Pharmacological:

1. Acetylcholinesterase Inhibitors: (Donepezil, Galantamine Rivastigmine)

   • Transdermal patch > oral

   • Improve/stabilise cognition, alertness and function (Good for Mild to Severe)

   • AEs: GIT sx, Brady, Neuro/Insomnia/Vivid dreams

2. NMDA Receptor Antagonists: (Memantine)

   • SHORT-TERM improve/stabilisation in cognition/function

   • Good for Moderate to Severe

Supportive Pharm:

1. SSRIs: comorbid depression, agitation/aggression

2. Trazodone/Melatonin: insomnia

Vascular Prevention: Antiplatelets (Aspirin), Anticoagulants (Apixiban, Rivaroxaban)

Lewy Body Motor Sx = Levodopa/Carbidopa

Antipsychotics for acute mx of behavioural disturbance in dementia should be avoided increased risk of AEs/mortality

Delirium (R1)

Disturbance in attention and awareness developing over a short period of time, is a change from baseline and fluctuates throughout the day (

Acute deterioration of mental state characterised by fluctuating sx of impaired attention, cognition and consciousness, typically developing over hours to days

Three Main Types:

1. Hyperactive (agitation, restless, delusions, hallucinations)

2. Hypoactive (quiet, withdrawn) - most common

3. Mixed (alternates b/w hyper and hypo)

Ix: identify cause (bloods, BGL, ECG, temp, urine)

Mx: reverse causes, low stimuli environment

• Avoid physical/chemical restraints (meds can worsen delirium)

• IV Thiamine 3-5d if alcohol withdrawal

• Antipsychotics if severe distress/hyperactive

  • Haloperidol, Olanzapine, Risperidol = Non Parkinson’s/Lewy Body Dementia

  • Quetiapine = Parkinson’s/LB Dementia

Demoralisation (R1)

Clinical/dysphoric state of existential distress characterized by:

• Helplessness

• ± Hopelessness

• ± Subjective incompetence/Loss of meaning or purpose

Often arising from chronic illness, severe stress, or perceived failure to cope

Unlike depression, focus is on subjective incompetence rather than anhedonia (pervasive loss of interest)

Mx: psychotherapy, supportive care

Suicidality/Suicide Attempt (R1)

Two Types:

1. Impulsive: short time between idea and action

2. Planned: long time between idea and action (stages include idea, plan/research, prep etc)

RF: static (fixed, historic), dynamic (fluctuates in duration and intensity)

Mx: safety planning, psycotherapy, verbal de-escalation, consider involuntary tx, limit access to toxic drugs (overdose)

Somatic Symptom Disorder (R2)

Neuropsychiatric condition causing somatic sx associated with significant distress or impairment

• Distressing physical sx (pain, fatigue, GI symptoms, etc.) that disrupt daily life, with/out medical explanation

• Excessive and persistent psychological responses

• Sx for >6m

Underlying cause not understood, psychological stressors may be a RF

Mx: CBT, Physiotherapy

Functional Neurological/Conversion Disorder (R2)

Neuropsychiatric condition causing somatic sx associated with significant distress or impairment

• Specific neurological (motor/sensory) signs and functional impairment

• Problems with movement or sensation (e.g. weakness, tremor, numbness, non‑epileptic seizures, speech/gait problems) that look like neurological disease (inconsistent findings)

Underlying cause not understood, psychological stressors may be a RF

Dx: ‘rule in’ features on neuro exam

• Sx improve with distraction

• Inconsistency on exam

• Patterns not matching known neuroanatomy

Mx: CBT, Physiotherapy, SSRIs etc (comorbid anx/dep)

Illness Anxiety Disorder (R2)

Disorder of health-related fear

Persistent fear/belief of having/developing a serious illness

• Excessive fear of illness with minimal to no physical/somatic sx

• Preoccupation with illness lasts ≥ 6m

• Behaviours include: Repeated reassurance-seeking, Excessive internet searching, Frequent doctor visits or avoidance of medical care

Mx: CBT, Anxiety Mx (SSRIs etc)

Psychological Factors Affecting Medical Conditions (R2)

• A) Medical condition/symptom is present

• B) Psychological/behavioural factors adversely affect the medical condition in one of:

  1. Influence the course of medical illness (e.g. cause exacerbation or trigger)

  2. Interfere with tx (e.g. poor adherence)

  3. Factors constitute additional well established health risks for the individual

  4. Influence the underlying pathophysiology, precipitating or exacerbating sx

• C) Not better explained by another mental disorder

Factitious Disorder (R3)

Patient consciously pretends to have physical sx without a clear secondary gain

• A) Falscification of physical or psychological signs/sx or induction of injury or disease, associated with identified deception

• B) The individual presents themself as unwell, injured or impaired

• C) The deceptive behaviour is evident even in the absence of obvious external rewards

• D) The behaviour is not better explained by another mental disorder e.g. delusional disorder

Can be Factitious disorder imposed on another (by proxy)

Malingering (R3)

Patient consciously pretends to have physical sx with a clear secondary gain

• A) Falscification of physical or psychological signs/sx or induction of injury or disease, associated with identified deception

• B) The individual presents themself as unwell, injured or impaired

• C) The deceptive behaviour is evident even in the presence of obvious external rewards

• D) The behaviour is not better explained by another mental disorder e.g. delusional disorder

Can be Factitious disorder imposed on another (by proxy)

Medication‑Induced Symptoms (R1)

Corticosteroids:

• Psychiatric AEs = euphoria, hypomania, depression, disturbances of mood, cognition, sleep and behaviour

• Delirium/psychosis are less common

Yasmin (OCP), Beta Blockers:

• Increased risk of depression

Ketamine

• Dissociation associated with confusion, fear or euphoria

Levodopa (Dopamine Agonist):

• AEs = depression, psychotic sx, impulse control disorders (e.g. gambling, hyper-sexuality, overspending, binge eating, inappropriate internet use)

Isotretinoin (Roaccutane - Acne):

• Dry skin & mucus membranes, depression

Levetiracetam (Keppra - Anticonvulsant):

• Behavioural changes (e.g. agitation, irritability, depressed mood, anxiety)

Endocrine‑Induced Symptoms (R1)

Pheochromocytoma:

• Classic triad of episodic headaches, tachycardia and sweating

• Can cause anxiety symptoms (e.g. panic attacks)

Cushing's Syndrome:

• Central obesity, proximal muscle wasting & hypertension

• Can cause depression, mania and psychosis

Polycycstic Ovarian Syndrome:

• Dx requires >2 of: Oligo/anovulation, Clinical or biochemical evidence of hyperandrogenism & polycystic ovaries

Hyperparathyroidism

• ‘Bones, stones, abdominal moans and psychic groans’

• Sx: renal stones and decreased bone density, fatigue, depressed mood, psychosis, cognitive dysfunction

Hyperthyroidism:

• Palpitations, heat intolerance, weight loss & sweating

• Anxiety, insomnia, depression, mania, psychosis

Hypothyroidism:

• Bradycardia, weight gain, cold intolerance, hair loss, fatigue, depression

Addison’s Disease:

• Fatigue, weight loss, salt craving, hyperpigmentation & hypotension

• Depression, psychosis, anxiety, mania (less common)