[MANUFACTURING PHARMACY] Solid Dosage Forms - Part 1

a. Diluent (Filler/ Bulking Agent)

Inert substance added to increase tablet size or fill the capsule body.

a. Diluent (Filler/ Bulking Agent)

b. Binder

c. Disintegrant

d. Superdisintegrant

e. Antifrictional

e. None

Which of the following is not a diluent?

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

e. None

f. All

Which of the following is/are diluent?

a. Dibasic calcium Phosphate

b. Mannitol

c. Xylitol

d. a and b

e. b and c

f. All

a. Lactose

Most common diluent and has no reactions with most drugs.

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

d. a and b - Lactose interact with basic substances such as stearates.

Lactose has no reactions with most drugs except:

a. Basic substances

b. Stearates

c. Neutral substances

d. a and b

e. b and c

f. All

a. Monohydrate

Form of lactose used for wet granulation.

a. Monohydrate

b. Anhydrous

c. Spray-dried

d. a and b

e. b and c

f. All

e. b and c

Anhydrous

Spray-dried

Form of lactose used for direct granulation.

a. Monohydrate

b. Anhydrous

c. Spray-dried

d. a and b

e. b and c

f. All

b. Sucrose and Dextrose

Used as sweetener.

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

c. Microcrystalline Cellulose

Avicel.

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

c. Microcrystalline Cellulose

Good flow and very compressible. It also disintegrates rapidly in water.

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

c. Microcrystalline Cellulose

Expensive thus usually combined with lactose.

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

e. All

Uses of starch:

a. Diluent

b. Binder

c. Disintegrant

d. a and b

e. All

d. Starch

Sta-Rx 1500®

Cellutab®

a. Lactose

b. Sucrose and Dextrose

c. Microcrystalline Cellulose

d. Starch

a. Dibasic calcium Phosphate

Only inorganic salt used as diluent.

a. Dibasic calcium Phosphate

b. Mannitol

c. Xylitol

d. a and b

e. b and c

f. All

e. b and c

Mannitol

Xylitol

Diluent used in chewable tablets.

a. PVP

b. Mannitol

c. Xylitol

d. a and b

e. b and c

f. All

b. Binder

Imparts cohesiveness to powders causing them to from granules.

a. Diluent (Filler/ Bulking Agent)

b. Binder

c. Disintegrant

d. Superdisintegrant

e. Antifrictional

d. None

Inadequate binder effects except:

a. Soft granules

b. Too much fines

c. Inadequately hard tablets

d. None

e. None

Too much binder effects except:

a. Too hard granules

b. Difficulty in screening

c. Hampered disintegration & dissolution d. Lower BA

e. None

f. None

Binder except:

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. Cellulose Derivatives

f. None

f. None

Binder except:

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. PVP

f. None

a. Starch paste

Binder of choice for wet granulation.

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. Polyvinyl Pyrrolidone

b. Acacia & Tragacanth

Natural gum binders.

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. Polyvinyl Pyrrolidone

b. 6:1

6 parts Acacia to 1 part Tragacanth

Usual ratio of Acacia to Tragacanth as binder.

a. 1:6

b. 6:1

c. 1:5

d. 5:1

c. Gelatin

Binder which is a protein substance.

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. Polyvinyl Pyrrolidone

d. Sucrose

Can be used as powder or syrup.

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. Polyvinyl Pyrrolidone

e. Microcrystalline cellulose

Cellulose derivatives are used as diluent, binder, and disintegrant except one which is not a binder. Which is it?

a. Methyl cellulose

b. Ethyl cellulose

c. Carboxymethyl cellulose

d. Hydroxypropyl methyl cellulose

e. Microcrystalline cellulose

e. Polyvinyl Pyrrolidone

Solubilizer for Iodine.

a. Starch paste

b. Acacia & Tragacanth

c. Gelatin

d. Sucrose

e. Polyvinyl Pyrrolidone

c. PVP

Mannitol and Xylitol are DILUENT.

Binder for chewable tablets.

a. Mannitol

b. Xylitol

c. PVP

d. a and b

e. All

c. Disintegrant

Facilitates the breakup of a tablet when in contact with aqueous medium.

a. Diluent (Filler/ Bulking Agent)

b. Binder

c. Disintegrant

d. Superdisintegrant

e. Antifrictional

a. External disintegrant

Added prior compression.

a. External disintegrant

b. Internal disintegrant

b. Internal disintegrant

Added prior granulation.

a. External disintegrant

b. Internal disintegrant

f. None

The following are disintegrant except:

a. Clay

b. Cellulose

c. Alginates

d. Gums

e. Ion exchange resin

f. None

e. Ion exchange resin

Polacrillin K is what type of disintegrant?

a. Clay

b. Cellulose

c. Alginates

d. Gums

e. Ion exchange resin

a. Swelling

MOA of disintegration with starch paste and alginates.

a. Swelling

b. Wicking

c. Release of gas

b. Wicking

MOA of disintegration with MCC.

a. Swelling

b. Wicking

c. Release of gas

c. Release of gas

MOA of disintegration with effervescent tablet.

a. Swelling

b. Wicking

c. Release of gas

e. All

Component of effervescent tablet:

a. NaHCO3

b. Citric acid

c. Tartaric acid

d. a and b

e. All

d. Superdisintegrant

Newer class of disintegrants which are effective at much lower levels and are hydroscopic.

a. Diluent (Filler/ Bulking Agent)

b. Binder

c. Disintegrant

d. Superdisintegrant

e. Antifrictional

f. All

The following are superdisintegrant:

a. Sodium Starch Glycolate

b. Crospovidone

c. Croscarmellose Na

d. a and b

e. b and c

f. All

a. Sodium Starch Glycolate

Explotab®

a. Sodium Starch Glycolate

b. Crospovidone

c. Croscarmellose Na

d. Superdisintegrant - This is a brand of Sodium Starch Glycolate.

What tablet component is Primojel®?

a. Diluent

b. Binder

c. Disintegrant

d. Superdisintegrant

e. Antifrictional

e. Antifrictional

Fine powders added prior to compression to reduce friction and improve flow properties.

a. Diluent

b. Binder

c. Disintegrant

d. Superdisintegrant

e. Antifrictional

a. 1%

Usual maximum concentration of anti-frictional.

a. 1%

b. 2%

c. 3%

d. 5%

a. Lubricant

Antifrictional which reduces friction between the tablet and die wall to facilitate ejection from die cavity.

a. Lubricant

b. Antiadherent

c. Glidant

b. Antiadherent

Antifrictional which reduces sticking to die walls and picking by punches.

a. Lubricant

b. Antiadherent

c. Glidant

c. Glidant

Antifrictional which reduces friction among particles to enhance the flow.

a. Lubricant

b. Antiadherent

c. Glidant

a. I, II, III

Stearates (Mg, Ca, Na).

I. Lubricant

II. Antiadherent

III. Glidant

a. I, II, III

b. I, II

c. III

d. I, III

b. I, II

Purified Talc

I. Lubricant

II. Antiadherent

III. Glidant

a. I, II, III

b. I, II

c. III

d. I, III

c. III

Colloidal talc

I. Lubricant

II. Antiadherent

III. Glidant

a. I, II, III

b. I, II

c. III

d. I, III

c. III

Colloidal SiO2

I. Lubricant

II. Antiadherent

III. Glidant

a. I, II, III

b. I, II

c. III

d. I, III

c. III

Ca and Mg silicates

I. Lubricant

II. Antiadherent

III. Glidant

a. I, II, III

b. I, II

c. III

d. I, III

d. Colloidal SiO2

Cab-O-Sil®

a. Stearates

b. Purified Talc

c. Colloidal Talc

d. Colloidal SiO2

e. Silicates

f. PEG and SLS

f. PEG and SLS

Only hydrophilic lubricants.

a. Stearates

b. Purified Talc

c. Colloidal Talc

d. Colloidal SiO2

e. Silicates

f. PEG and SLS

a. Colorant

Disguises off-color drugs and improves appearance

a. Colorant

b. Flavorant

c. Sweetener

f. All

Dyes:

a. Synthetic organic colorants

b. Water-soluble

c. Used in solution form

d. a and b

e. b and c

f. All

f. All

Lakes:

a. Dyes adsorbed on an inorganic oxide

b. Water-insoluble

c. Used in fine dispersion or suspension form

d. a and b

e. b and c

f. All

a. Blue No. 1

Brilliant Blue FCF

a. Blue No. 1

b. Blue No. 2

c. Green No. 3

d. Red No. 3

e. Red No. 40

b. Blue No. 2

Indigotin

a. Blue No. 1

b. Blue No. 2

c. Green No. 3

d. Red No. 3

e. Red No. 40

c. Green No. 3

Fast Green FCF

a. Blue No. 1

b. Blue No. 2

c. Green No. 3

d. Red No. 3

e. Red No. 40

d. Red No. 3

Erythrosine

a. Blue No. 1

b. Blue No. 2

c. Green No. 3

d. Red No. 3

e. Red No. 40

e. Red No. 40

Allura Red AC

a. Blue No. 1

b. Blue No. 2

c. Green No. 3

d. Red No. 3

e. Red No. 40

a. Yellow No. 5

Tartrazine

a. Yellow No. 5

b. Yellow No. 6

c. Green No. 3

d. Red No. 3

e. Red No. 40

b. Yellow No. 6

Sunset Yellow FCF

a. Yellow No. 5

b. Yellow No. 6

c. Green No. 3

d. Red No. 3

e. Red No. 40

b. Flavorant

Masks the unpleasant taste of the drug.

a. Colorant

b. Flavorant

c. Sweetener

a. Salty

The following are flavorant for which taste?

Cinnamon

Orange cherry

Butterscotch

a. Salty

b. Bitter

c. Sour

d. Oily

e. Unpleasant

b. Bitter

The following are flavorant for which taste?

Chocolate

Cherry

Raspberry

Mint

a. Salty

b. Bitter

c. Sour

d. Oily

e. Unpleasant

c. Sour

The following are flavorant for which taste?

Raspberry

Lemon

Fruity

a. Salty

b. Bitter

c. Sour

d. Oily

e. Unpleasant

d. Oily

The following are flavorant for which taste?

Lemon

Orange

Mint

a. Salty

b. Bitter

c. Sour

d. Oily

e. Unpleasant

e. Unpleasantly sweet

The following are flavorant for which taste?

Vanilla

Fruity

a. Salty

b. Bitter

c. Sour

d. Oily

e. Unpleasantly sweet

a. Blending

Flavoring techniques employed in Vanillin, MSG, and Benzaldehyde.

a. Blending

b. Overshadow

c. Physical

d. Chemical

e. Physiological

b. Overshadow

Flavoring techniques employed in methylsalicylate, glycyrrhiza, oleoresins.

a. Blending

b. Overshadow

c. Physical

d. Chemical

e. Physiological

b. Glycyrrhiza

Incorporate very long lasting sweetness.

a. Methylsalicylate

b. Glycyrrhiza

c. Oleoresins

d. a and be

e. All

c. Physical

Flavoring techniques employed including formation of insoluble compounds, emulsification of oils, effervescence, increasing viscosity of liquids, and coating of tablets.

a. Blending

b. Overshadow

c. Physical

d. Chemical

e. Physiological

a. W/O - since this will be insoluble on the saliva

Emulsion form that will mask the unpleasant taste.

a. W/O

b. O/W

c. Physical

Flavoring techniques employed in coating of tablets.

a. Blending

b. Overshadow

c. Physical

d. Chemical

e. Physiological

d. Chemical

Flavoring techniques employed by absorption of the drug on a substrate and formation of a complex of drug.

a. Blending

b. Overshadow

c. Physical

d. Chemical

e. Physiological

a. True

Chloramphenicol palmitate is the form of chloramphenicol that is tasteless.

a. True

b. False

e. Physiological

Flavoring techniques employed by anesthetizing taste buds with menthol or mint flavors.

a. Blending

b. Overshadow

c. Physical

d. Chemical

e. Physiological

c. Sweetener

Masks the unpleasant taste of the drug.

a. Colorant

b. Flavorant

c. Sweetener

e. None

Nutritive sweetener except:

a. Sucrose

b. Fructose

c. Dextrose

d. High-fructose corn syrup

e. None

e. None

Non nutritive sugar alcohols except:

a. Mannitol

b. Xylitol

c. Sorbitol

d. Erythritol

e. None

a. Sucralose

1000x sweet than sucrose.

a. Sucralose

b. Saccharin

c. Na Saccharin

d. Acesulfame K

b. Saccharin

500x as sweet as sucrose.

a. Sucralose

b. Saccharin

c. Na Saccharin

d. Acesulfame K

c. Na Saccharin

300x as sweet as sucrose.

a. Sucralose

b. Saccharin

c. Na Saccharin

d. Acesulfame K

e. b and c

180-200x as sweet as sucrose.

a. Na Saccharin

b. Acesulfame K

c. Aspartame

d. Na cyclamate

e. b and c

d. Na cyclamate

30x as sweet as sucrose.

a. Na Saccharin

b. Acesulfame K

c. Aspartame

d. Na cyclamate

d. Na cyclamate

Magic sugar.

a. Na Saccharin

b. Acesulfame K

c. Aspartame

d. Na cyclamate

e. Stevia

e. Stevia

Natural sweetener 30x as sweet as sucrose.

a. Na Saccharin

b. Acesulfame K

c. Aspartame

d. Na cyclamate

e. Stevia