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0-12 Gross
None
0-12 Micro
Coagulation necrosis, Edema, Hemorrage
12-24 Gross
Dark mottling
12-24 Micro
Coagulation necrosis, pyknotic nuclei, Hypereosinophilia, contraction band necrosis, neutrophilic infiltrate
24-72 Gross
Yellow-tan
24-72 Micro
Coagulative necrosis, loss of myocyte nuclei, loss of muscle striations, lots of neutrophils
3-7 days gross
Hyperemic border, yellow tan, removal of dead tissue
3-7 days micro
dead myofibirils removed, neutrophils disappear, macrophage infiltration
7-14 Gross
yellow tan (max), soft
7-10 Micro
Granulation tissue
2-8 weeks gross
gray-white scar
2-8 weeks micro
collagen deposition, decreased cellularity
2 months gross
Scarring
2 months micro
dense collagen layer