Vaginal, Rectal, and Suppositories Practice Questions - Pharmaceutics II

Which of the following is an advantage of vaginal drug delivery?

- Extensive Hepatic Metabolism

- High Enzymatic Degradation

- Avoidance of First-Pass Metabolism

- Increased Systemic Toxicity and Side Effects

Avoidance of First-Pass Metabolism

Which mechanism of Vaginal drug absorption is primarily associated with Lipophilic Drugs?

Transcellular Transport

Which of the following is an example of a Mucoadhesive Agent used in vaginal formulations?

- Sodium Chloride and Glucose

- Natural Polymers, like Hyaluronic Acid

- Cosolvents like PEG / Glycerin

- Bile Salts

Natural Polymers, like Hyaluronic Acid

Which of the following best defines Rectal Drug Delivery?

- Administration of Drugs via the GIT for Systemic Action

- Administration of Pharmaceutical Preparations via the Rectum for Local or Systemic Effect

- Delivery of Drugs through the Skin for Topical Action

- Injection of Drugs into Muscle Tissue

Administration of Pharmaceutical Preparations via the Rectum for Local or Systemic Effect

Which of the following is a solid dosage form used in rectal drug delivery?

- Enema

- Cream

- Suppository

- Gel

Suppository

Which of the following is a disadvantage of Rectal drug delivery?

- Complete First-Pass Metabolism

- Large Absorption Surface Area

- Erratic Absorption

- High Fluid Volume in Rectum

Erratic Absorption

A drug has high hepatic first-pass metabolism when given orally. To avoid this problem, which rectal administration strategy would best improve its systemic availability?

- Insert the drug deep into the upper rectum

- Insert the drug into the lower rectum

Insert the drug into the lower rectum

A formulation scientist is developing a rectal suppository but observes inconsistent drug absorption. Which physiological factor is most likely responsible?

- Large Fluid Volume in the Rectum

- Presence of Villi and Microvilli

- Small and Variable Fluid Content

- High Enzymatic Activity

Small and Variable Fluid Content

Which of the following best defines a suppository?

- Solid dosage form for administration to any route

- Medicated dosage form inserted into body orifices

- Semi-solid dosage form applied topically

Medicated dosage form inserted into body orifices

Which suppository base melts at body temperature?

Theobroma Oil (Cocoa Butter)

Why should water generally be avoided in Suppository formulations?

Promotes microbial growth and degradation

Which factor primarily determines the rate of drug release from a suppository?

- Color and shape of the base

- Melting and dissolution characteristics of the base

- Standard methods of preparing suppository

Melting and Dissolution characteristics of the base

A pharmacist prepares suppositories using glycerinated gelatin. After a few days, the suppositories between sticky and deformed. What is the MOST likely cause?

- Oxidation of the base

- Hygroscopic nature of the base

- Excessive brittleness

- Polymorphism

Hygroscopic nature of the base