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What factors led to the development of the germ theory?
Individuals
War
Government
Science and Technology
Why did government lead to the development of germ theory?
The French government paid Pasteur to hire research assistants to prove the germ theory was correct
Government built sewers to keep streets clean and provide clean water
Why did science and technology lead to the development of germ theory?
Joseph Lister used carbolic spray to perform the first antiseptic surgery
Scientists developed first chemical drugs
Pasteur and Koch benefited from improved microscopes
Pasteurisation
How did individuals lead to the development of germ theory?
Persuaded bad air wasn’t the cause of disease
Wanted to be successful for their country
France recently lost the Franco Prussian war to Germany so both men were competing against each other for the medical break through
How did Louis Pasteur lead to the development of germ theory?
Published germ theory in 1861
French
Created vaccines
Germs caused disease in animals too by investigating silk worms
Proves milk goes off because of bacteria PASTEURISATION
Germs from the air cause disease
Using Kochs findings he developed a vaccine against anthrax
How did Robert Koch lead to the development of germ theory?
German
Made rodents sick to prove germ theory
Found specific bacterium that causes cholera
Isolated anthrax bacteria in 1876
Interested in Pasteurs work
Identified 21 diseases
Investigated tuberculosis by staining it to see it and so it could be photographed
Specific baterium causes disease proof to Pasteurs theory
How was war a factor to the development of germ theory?
Franco Prussian war 1870-1871
France vs Germany
France won
What are some early types of anaesthetic?
Herbs and alcohol
Speed
Laughing gas
Ether
Is chloroform an anaesthetic or antiseptic?
anaesthetic
Is carbolic acid an anaesthetic or antiseptic?
Antiseptic
Why did many patients die during operations?
Shock of pain and infections
What 4 things were surgeons doing?
Reused bandages spreading infections
Didn't wash hands before operations
Didnt sterilise their equipment
Operated wearing old blood stained clothes
How did Lister realise antiseptic worked?
reduced smell of sewage and destroyed parasites
How did people use carbolic acid during operations?
On bandages and used to treat people will compound fractures
Who was Harrah Greene?
Died of chloroform when getting a toenail removed
Who praised chloroform after child birth?
Queen Victoria
What is aseptic surgery?
Completely germ free surgery
Who discovered carbolic acid?
Joseph Lister
who discovered Chloroform?
Simpson
What is a positive of chloroform?
More complex operations can take place
surgeons could work slower and more carefully
What are the negatives of Chloroform?
Slower operations
When was the great stink?
1858 in London
Why did the great stink happen?
London was overpopulated and was a very hot summer so the thick layer of sewage made the smell unbearable
what closed dourn because of the great stink?
Houses of Parliament
How many people lived in London by the 1850s?
2.5 million
what did people believe caused the great stink?
miasma
when was the cholera epidemics? ( 4 outbreaks over what time period )
1831- 1865
the epidemic of 1848-49 killed how many people?
53293
who published a report and on what?
Edwin chadwick in 1842 'report on the sanitary conditions of the laboring population'
what 2 places did he pick to look at?
Liverpool and Rutland
what did his report show?
living Conditions in industrial cities were very poor as badly ventilated houses were dose wegether so disease spread quickly
working conditions were harmful as 12hr days were common in hot and dirty workshops
fresh food was hard to get
Doctors were expensive
water supply was hard to get and dirty
What methods did people use to to try and prevent cholera?
Burned barrels of tar/vinegar to remove bad air
Smoked cigars as protection against bad air
Praying
Wearing charms
Pills that granted protection
Cleaning houses
Chloride of lime arounc houses
Burning clothes or bedding of victims
What did people think caused cholera?
Miasma
Punishmenr by God
Where did John Snow identify was causing the cholera?
Broad street pump
How did Snow prove this?
Mapped out the deaths in detail by asking locals and then removed the pump
What was discovered near the pump?
Cesspit
Did everyone beleive Snow?
Not everyone
What were problems with the old sewers?
Designed to remove surface water
Who was in charge if making new sewers and what was his job called and when did he get it?
Joseph Bazalgette cheif engineer of the metropolitan board of works in 1856
Name important people who beleived that cholera wss caused by miasma
Florence Nightengale
William Farr
Edwin Chadwich
What scheme did Bazalgette develop?
New sewers using gravity to remove sewage from london but is expensive
Why did the government oppose his plan?
Sewage could flow back to London
Why did the governemnt change their mind?
Great stink in 1858 was unbearable
What shape should the sewers be?
circular to withstand pressure
what type of cement was used?
portland cement - hardens on contact with water to last many years
What happened in the Eastend 1862?
gas main fractured and exploded
rovirars workers cling too close to evilwars and sever collapsed
burried under earth and timber after collapse 3 survives 2 dead I missing
what was wrong with the reservoir?
sevage was entering water supplies
Why did William Farr change his mind about what caused cholera?
smell had gone but chovera had come back
Why did they do the right thing for the wrong reason?
removed smell to stop miasma but also removed sewage from entering drinking water.
what was bazalgette described as in 1890?
choleras deadliest enemy
who discovered magic bullets?
Paul Ehrlich but they were dangerous and inasectime
when did Pasteur leave charles Chamberland and to do what?
1880 to innoculate chickens with the germ what caused chicken cholera but he forgot so innoclated them after the summer and they didn't die as va.cinations were weakened