Nuclear Import (Topic 7)

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Last updated 1:46 AM on 4/12/26
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8 Terms

1
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1.

Importin binds to NLS in cargo protein

<p>Importin binds to NLS in cargo protein</p>
2
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2.

Cargo translocates through nuclear pore

  • importin interacts with FG-Nups

<p>Cargo translocates through nuclear pore</p><ul><li><p>importin interacts with FG-Nups</p></li></ul><p></p>
3
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3.

In the nucleus, importin binds to Ran-GTP

  • cause a conformational change in importin

<p>In the nucleus, importin binds to Ran-GTP</p><ul><li><p>cause a conformational change in importin</p></li></ul><p></p>
4
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4.

Cargo protein is released

<p>Cargo protein is released</p>
5
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5.

Importin/Ran-GTP complex diffuses back into cytoplasm

<p>Importin/Ran-GTP complex diffuses back into cytoplasm</p>
6
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6.

Ran-GTP interacts with GAP

  • GTP is hydrolyzed to GDP on Ran

<p>Ran-GTP interacts with GAP</p><ul><li><p>GTP is hydrolyzed to GDP on Ran</p></li></ul><p></p>
7
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7.

Affinity of importin/Ran binding is reduced

  • importin dissociates

  • free to pick up more cargo

8
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8.

Ran-GDP travels through NPC back to nucleus

  • interacts with GEF

  • Ran releases GDP and binds to GTP