השתלת מח עצם

bone marrow transplant

standard treatment of leukemia patients that are in remission

Autologous Transplant

transplant of the patient’s own bone marrow

Allogenic Transplant

bone marrow transplant from a donor

indications for an autologous transplant

when there is a need for high levels of chemotherapy that will disturb the bone marrow. Bone marrow is removed from the patient, chemotherapy is performed, and then the bone marrow is returned to the patient

multiple myeloma and lymphoma

which type of blood cancers are autologous transplants a treatment for

complications of autologous transplants

infections, damage from the chemotherapy, return of the disease

leukemia

which type of blood cancer is an allogenic transplant used for

HLA

this must match between the patient and bone marrow donor

phase 0 of transplant

preparation of donor and collection of cells

phase 1 of transplant

conditioning phase. Give the patient chemotherapy and radiation in order to ensure that the bone marrow space is empty

phase 2 of transplant

transplant of the bone marrow through an IV

phase 3 of transplant

engraftment. Movement of the transplant cells to the bone marrow

10 days

how long does engraftment take in an autologous transplant

2-3 weeks

how long does engraftment take in an allogenic transplant

GCSF injections

given to the patient after the bone marrow transplant in order to decrease NADIR time

engraftment syndrome

rash, fever, and fluid retention due to a lymphocyte reaction to the transplant. It is treated with steroids

GVHD

occurs after the transplant is accepted. The transplant recognizes the body as foreign and begins to attack it

chronic GVHD

occurs after 100 days or during 100 days after the transplant with light symptoms. It can cause scleroderma, liver and intestinal problems, chronic dryness of the eyes