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Genetic Exp. for OCD
Candidate Genes
Example of a candidate gene
5H1-D
Polygenic
Several genes are involved in OCD
Aetioologically Heterogenous
The origin of OCD has different causes
Neural Exp. for OCD
Low serotonin levels
What causes impaired decision making?
An abnormal functioning frontal lobe
What does a faulty parahippocampal gyrus cause?
Abnormal processing of unpleasant emotions
Supporting Evidence for the Genetic Exp. - Twin studies
Nestadt et al
What did Nestadt et al find?
68% of MZ twins shared OCD vs 31% of DZ twins
What did Cromer et al find?
Over half of OCD patients had experienced a traumatic event in the past
Supporting Evidence for Neural exp.
Antidepressants
What are antidepressants also effective on, other than inc. serotonin levels?
Reducing OCD symptoms