immuno quiz 4-5

Which of the following is a correct example of the concept of allelic exclusion?

A. If TdT expression is high in the TCRB chain, TdT expression is low in TCRa

B. If TdT expression is high in IgH, TdT expression is low in IgL.

C. If recombination is successful in IgH, recombination does not proceed in IgL 

D. If recombination is successful in Igk, recombination does not proceed in Iglambda

D. If recombination is successful in Igk, recombination does not proceed in Iglambda

2. A given antibody binds to a pathogen and serves as an opsonin to induce Fc receptor-mediated phagocytosis. Which of the following best describes a possible isotype and Fc receptor pair that could mediate this response?

A. IgM : FcyR

B. IgM: FcuR

C. IgG : FcyR

D. IgG: FcuR

C. IgG : FcyR

3. Which of the following roles are performed by Syk family kinases?

A. Antigen recognition

B. Phosphorylation of ITAMs

C. Phosphorylation of other Syk family kinases

D. Phosphorylation of adaptor proteins

D. Phosphorylation of adaptor proteins

4. Immunoglobulin can be enzymatically cleaved into functional fragments. Which of the following are produced following cleavage with papain?

A. One Fab and two Fc

B. Two Fab and one Fc

C. One light chain and two heavy chains

D. Two light chains and one heavy chain

B. Two Fab and one Fc

Which of the following is not involved in class switch recombination?

A. RSS

B. UNG and APE

C. Constant heavy region-encoding exons

D. Switch regions

A. RSS

Recombined genes encoding Immunoglobulin light chains contain which of the following segments?

A. D and J

B. V and D 

C. V and J

D. V, D, and J

C. V and J

7. An immunoglobulin exhibits weak noncovalent interactions between an individual Fab and its target antigen. However, it exhibits a great number of multivalent interactions.

Which of the following describes the interaction strength of this immunoglobulin?

1. Low affinity, low avidity

2. Low affinity, high avidity

3. High affinity, low avidity

4. High affinity, high avidity

2. Low affinity, high avidity

Class switch recombination is initiated by the enzyme and impacts Ig -

A. RAG: antigen specificity

B. RAG: effector function

C. AID: antigen specificity

D. AID: effector function

D. AID: effector function

9. Which of the following proteins opens DNA hairpins in coding joints, generating P nucleotides?

A. RAG-1:2

B. Ku70:Ku80

C. DNA-PK:Artemis

D. DNA ligase:XRCC4

C. DNA-PK:Artemis

10. Which of the following is false regarding the T cell receptor complex?

1. It contains ß2 microglobulin

2. It contains the CD8 coreceptor in cytotoxic T cells

3.  It contains the CD4 coreceptor in helper T cells

4. It contains both TCR a and ß chains

1. It contains ß2 microglobulin