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These flashcards cover the key terms and concepts related to hematopoiesis, including processes of erythropoiesis and leukopoiesis.
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Hematopoiesis
The formation of the formed elements of blood, including red blood cells, white blood cells, and platelets.
What is a haematopoietic stem cell (HSC)?
A multipotent stem cell in the red bone marrow that can differentiate into all types of blood cells, forming either myeloid or lymphoid lineages.
What are the two main lineages of blood cells derived from HSCs?
Myeloid lineage → RBCs, platelets, granulocytes, monocytes
Lymphoid lineage → B cells, T cells, NK cells
What is erythropoiesis?
The production of red blood cells (RBCs) in the bone marrow, stimulated by erythropoietin (EPO) from the kidneys in response to low oxygen levels.
What is leukopoiesis?
The production of white blood cells (WBCs) in the bone marrow, regulated by cytokines and growth factors.
How does erythropoietin (EPO) regulate RBC production (especially if O2 is low)?
The kidneys detect low oxygen → release EPO → stimulates erythropoiesis in the red bone marrow → increases RBCs → improves oxygen transport.
Key difference between erythropoiesis and leukopoiesis?
Erythropoiesis → RBCs, controlled mainly by EPO
Leukopoiesis → WBCs, controlled by cytokines and growth factors.