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Why are multiple animal models used?
To address different risks (efficacy, safety, translation to humans)
What are the main categories of animal models?
Small animal, large animal, disease-specific models
What are small animals used for?
Early proof-of-concept
What are large animals used for?
Human-like physiology and IND-enabling studies
How do you choose an in vivo model?
Match the human condition (organ, function, clinical use)
What must you include in an answer?
Animal + anatomical site + justification
Why is anatomical site important?
It determines relevance (load, function, tissue typ