[ANALYSIS-LAB-FIN-03-PT1] DISSOLUTION TESTING APPARATUS

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THIS FLASHCARDS IS ABOUT [ANALYSIS] DISSOLUTION.

QUALITY ANALYSIS

QUALITY CONTROL

Last updated 2:20 PM on 4/14/26
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34 Terms

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Dissolution

This is the process by which a solid solute enters in to a solution (i.e., mass transfer from solid surface to liquid phase).

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  • Estimation of amount of drug released per unit time

  • Batch to batch quality control

  • It is the rate limiting factor for poorly soluble drugs

  • For product development

What are the (4) Importance of Dissolution?

Hint: EBIF

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Info

The estimation of amount of drug released per unit time has something to do with bioavailability.

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Irreversible

Rate limiting steps are?

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7

How many types are there for the classification of dissolution apparatus?

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Basket Apparatus

Classification of Dissolution Apparatus:

What is TYPE 1 in USP?

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Paddle Apparatus

Classification of Dissolution Apparatus:

What is TYPE 2 in USP?

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Reciprocating Cylinder

Classification of Dissolution Apparatus:

What is TYPE 3 in USP?

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Flow Through Cell

Classification of Dissolution Apparatus:

What is TYPE 4 in USP?

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Paddle Over Disk

Classification of Dissolution Apparatus:

What is TYPE 5 in USP?

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Rotating Cyclinder

Classification of Dissolution Apparatus:

What is TYPE 6 in USP?

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Reciprocating Holder

Classification of Dissolution Apparatus:

What is TYPE 7 in USP?

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  1. Basket Apparatus

  2. Paddle Apparatus

  3. Reciprocating Cylinder

  4. Flow Through Cell

  5. Paddle Over Disk

  6. Rotating Cylinder

  7. Reciprocationg Holder

What are the (7) Types of Classification of Dissolution Apparatus in USP?

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Paddle Apparatus

Classification of Dissolution Apparatus:

What is TYPE 1 in Indian Pharmacopeia?

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Basket Apparatus

Classification of Dissolution Apparatus:

What is TYPE 2 in Indian Pharmacopeia?

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  1. Paddle Apparatus

  2. Basket Apparatus

What are the (2) Types of Classification of Dissolution Apparatus in IP?

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Basket Apparatus

Classification of Dissolution Apparatus:

What is TYPE 1 in British/European Pharmacopeia?

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Paddle Apparatus

Classification of Dissolution Apparatus:

What is TYPE 2 in British/European Pharmacopeia?

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Flow Through Cell

Classification of Dissolution Apparatus:

What is TYPE 3 in British/European Pharmacopeia?

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Reference

knowt flashcard image
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  1. Rotating Bottle Apparatus

  2. Diffusion Cell

  3. Peristalsis Cell

  4. Intrinsic Dissolution Method

What are the (4) USP Dissolution Apparatus (Non-Official)?

Hint: Rot-Diff-Peris-In

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  1. Borosilicate Glass

  2. Semi hemispherical bottom

  3. 1,000 mL

TYPE 1 — ROTATING BASKET:

Design: Vessel

  • It is made of (1)_____ glass

  • (2)__________ bottom

  • The capacity is (3)_____ mL

<p><strong><u>TYPE 1 — ROTATING BASKET</u>:</strong></p><p></p><p><strong>Design: </strong>Vessel</p><ul><li><p>It is made of <strong><em>(1)_____ glass</em></strong></p></li><li><p><strong><em>(2)__________ bottom</em></strong></p></li><li><p>The capacity is <strong><em>(3)_____ mL</em></strong></p></li></ul><p></p>
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  1. Stainless steel 316

  2. 50-100 rpm

TYPE 1 — ROTATING BASKET:

Design: Shaft

  • It is made from (1) Stainless __________

  • Its speed is (2)________ rpm

<p><strong><u>TYPE 1 — ROTATING BASKET</u>:</strong></p><p></p><p><strong>Design: </strong>Shaft</p><ul><li><p>It is made from <strong><em>(1) Stainless __________</em></strong></p></li><li><p>Its speed is <strong><em>(2)________ rpm</em></strong></p></li></ul><p></p>
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37 ± 0.5°C

TYPE 1 — ROTATING BASKET:

Design: Water Bath

  • It is maintained at what temperature (°C)?

<p><strong><u>TYPE 1 — ROTATING BASKET</u>:</strong></p><p></p><p><strong>Design: </strong>Water Bath</p><ul><li><p>It is maintained at what temperature (°C)?</p></li></ul><p></p>
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Basket

TYPE 1 — ROTATING BASKET:

  • The dosage form is kept in a?

<p><strong><u>TYPE 1 — ROTATING BASKET</u>:</strong></p><ul><li><p>The dosage form is kept in a?</p></li></ul><p></p>
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  • Tablets

  • Capsules

  • Floating dosage forms

TYPE 1 — ROTATING BASKET:

  • This is used for what dosage forms (3)?

<p><strong><u>TYPE 1 — ROTATING BASKET</u>:</strong></p><ul><li><p>This is used for what dosage forms (3)?</p></li></ul><p></p>
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  1. Borosilicate Glass

  2. Semi hemispherical bottom

  3. 1,000 mL

TYPE 2 — PADDLE APPARATUS:

Design: Vessel

  • It is made of (1)_____ glass

  • (2)__________ bottom

  • The capacity is (3)_____ mL

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><p></p><p><strong>Design:</strong> Vessel</p><ul><li><p>It is made of <strong><em>(1)_____ glass</em></strong></p></li><li><p><strong><em>(2)__________ bottom</em></strong></p></li><li><p>The capacity is <strong><em>(3)_____ mL</em></strong></p></li></ul><p></p>
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Blade

TYPE 2 — PADDLE APPARATUS:

Design: Shaft

  • It is fused with _____ at bottom

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><p></p><p><strong>Design:</strong> Shaft</p><ul><li><p>It is fused with<strong><em> _____</em></strong> at bottom</p></li></ul><p></p>
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Teflon

TYPE 2 — PADDLE APPARATUS:

Design: Stirring Elements

  • It is coated with?

(For laboratory purpose stainless steel is used)

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><p></p><p><strong>Design:</strong> Stirring Elements</p><ul><li><p>It is coated with?</p></li></ul><p></p><p><em>(For laboratory purpose </em><strong><em><u>stainless steel</u></em></strong><em> is used)</em></p>
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25-50 rpm

TYPE 2 — PADDLE APPARATUS:

  • What is the rotation speed of the apparatus?

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><ul><li><p>What is the <strong>rotation speed</strong> of the apparatus?</p></li></ul><p></p>
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37 ± 0.5°C

TYPE 2 — PADDLE APPARATUS:

Design: Water Bath

  • It maintains at what temperature (°C)?

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><p></p><p><strong>Design:</strong> Water Bath</p><ul><li><p>It maintains at what temperature (<span>°C)?</span></p></li></ul><p></p>
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Platinum Wire

TYPE 2 — PADDLE APPARATUS:

Design: Sinkers

  • What wire is used to prevent tablet/capsule from floating?

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><p></p><p><strong>Design:</strong> Sinkers</p><ul><li><p>What <strong>wire</strong> is used to prevent tablet/capsule from floating?</p></li></ul><p></p>
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Info

TYPE 2 — PADDLE APPARATUS:

  • The dosage form should remain at the bottom center of vessel

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><ul><li><p>The <strong>dosage form</strong> should remain at the <u>bottom center</u> of vessel</p></li></ul><p></p>
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  • Orally disintegrating tablets

  • Chewable tablets, etc.

TYPE 2 — PADDLE APPARATUS:

  • This is used for what dosage forms (2)?

<p><strong><u>TYPE 2 — PADDLE APPARATUS</u>:</strong></p><ul><li><p>This is used for what dosage forms (2)?</p></li></ul><p></p>