hematology and hemostasis 1

blood

bathes all tissues

essential for water/electrolyte balance

temp control

immune system

blood cells

made in bone marrow

hematopoiesis

production of blood cell and platelets and from stem cells

hematopoietic disorders

abnormalities, inflammation, neoplasia, anemia

hemostasis

stoppage of blood flow

elements of blood

RBC, WBC, platlets

ertythropoietin

hormone produces by kidney

Hematocrit and PCV

Plasma, Buffy coat, RBCs

mammals

non nucleated mature RBCs

Bird/reptiles

nucleated mature RBCs

basophilic stippling

small dark blue bodies in RBCs

Howell-jolly bodies

basophilic nuclear remnants-anemia

nucleated RBCs- nRBCs

early release of immature cells-anemia

Heinz bodies

denatured hemoglobin- 5% cats normal

Mycoplasma hemofelis

bacteria flea bite

bartonella- cat

flea and tic

cat scatch disease-people

induce inflammation

ring and rod forms

azithromycin

babesia-canine

tick borne protozoal blood parasite

hemolytic anemia, thrombocytopenia lethargy, splenomegaly

azithromycin

coagulation

process of clotting

vascular response

smooth muscle contracts when vessel damaged- narrows lumen which causes decreased blood flow

platelets

become sticky an form plug

clot retraction

platelets release thrombosthenin which causes shrinkage

clotting cascade

blood clotting factors for a network the attaches platelet plug and trap cells

coagulation test evaluates hemostatic mechanisms

platelet count/estimate, whole blood clotting time(2 to 10 mins), buccal clotting time(1 to 5 minutes), Fibrinogen Degradation Product(FDP), Prothrombin(PT) and Activated Partial Prothrombin Time(APTT)

fibrinogen

synthesized by liver

precursor to fibrin

need for clot formation

collecting/handling samples

enough blood, venous blood, invert, reduce stress, refrigerate

plasma

liquid portion of blood and clotting factors

Serum

no clotting factors