Antibiotics: Nucleic Acid Synthesis Inhibitor
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Last updated 8:24 PM on 3/18/23
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10 Terms
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classes of nucleic acid inhibitors
quinolones, mitroimidazoles, acid-fast drugs
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quinolones
ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, nalidixic acid
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ciprofloxacin
nucleic acid inhibitor, target DNA gyrase and topoisomerase IV to prevent DNA replication, G-/G+, many side effects, rarely given to children/elderly/pregnant/nursing
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levofloxacin
nucleic acid inhibitor, target DNA gyrase and topoisomerase IV to prevent DNA replication, G-/G+, many side effects, rarely given to children/elderly/pregnant/nursing
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moxifloxacin
nucleic acid inhibitor, target DNA gyrase and topoisomerase IV to prevent DNA replication, G-/G+, many side effects, rarely given to children/elderly/pregnant/nursing
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ofloxacin
nucleic acid inhibitor, target DNA gyrase and topoisomerase IV to prevent DNA replication, G-/G+, many side effects, rarely given to children/elderly/pregnant/nursing
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nalidixic acid
nucleic acid inhibitor, target DNA gyrase and topoisomerase IV to prevent DNA replication, G-/G+, many side effects, rarely given to children/elderly/pregnant/nursing
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nitroimidazoles
“-nidazole”, produce ROS that damage DNA, depletes thiol (cofactor for both polymerases), anaerboic bacteria as well as some parasitic infections
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clofazimine
nucleic acid inhibitor, bind to guanine to prevent replication and transcription, acid fast
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rifamycin
rifampin, rifaximin, bind to RNA polymerase to prevent transcription, acid fast (and some select G-/G+)