Biopsychology Exam 3

Affect

An emotional process that includes moods, subjecting feelings, and discrete emotions (experiences of emotions, moods, feelings)

Affective Neuroscience

The study of how the brain and nervous system process emotions, how the brain creates emotional responses. Emotions are psychological phenomena that involve changes to the body (e.g., facial expression), changes in autonomic nervous system activity, feeling states (subjective responses), and urges to act in specific ways (motivations). Aims to understand how matter (brain structures and chemicals) creates one of the most fascinating aspects of the mind-emotions. Uses unbiased, observable measures that provide credible evidence. Leads to biologically based treatments for affective disorders, such as depression and bipolar disorder

The Neural System of Reward Seeking (Desire)

One of the most important affective neuronal systems relates to feelings of desire or the appetite for rewards. Researchers refer to these appetitive (natural desire to satisfy bodily needs) processes using terms such as “wanting”, “seeking”, or “behavioral activation sensitivity”. When the appetitive system is aroused, the organism shows enthusiasm, interest, and curiosity. These neural circuits motivate the animal to move through its environment in search of rewards such as appetizing foods, attractive sex partners, and other pleasurable stimuli. When the appetitive system is underaroused, the organism appears depressed and helpless.

Brain Regions Involved in the Desire System

When an electrode is implanted in the lateral hypothalamus or in cortical or mesencephalic regions to which the hypothalamus is connected, animals will press a lever to deliver electrical stimulation, suggesting that they find the stimulation pleasurable.  Other regions in the desire system also include the amygdala, nucleus accumbens, and frontal cortex. The neurotransmitter dopamine, produced in the mesolimbic and mesocortical dopamine circuits, activates these regions. It creates a sense of excitement, meaningfulness, and anticipation. These structures are also sensitive to drugs such as cocaine and amphetamines, chemicals that have similar effects to dopamine. Research in both humans and nonhuman animals shows that the left frontal cortex is more active during appetitive emotions such as desire and interest.

The Neural Circuits of Pleasure and Enjoyment (Liking)

Surprisingly, the amount of desire an individual feels toward a reward need not correspond to how much they like that reward. The neural structures responsible for enjoying rewards differ from those involved in desiring rewards. “Liking” (e.g., enjoyment of a sweet liquid) can be measured in babies and nonhuman animals by measuring licking speed, tongue protrusions, and happy facial expressions, whereas “wanting” (desire) is shown by the willingness to work hard to obtain a reward.  For example, drug addicts often desire drugs even when they know that the ones available will not provide pleasure.

Brain Regions Involved in the Liking System

Research on liking has focused on a small area within the nucleus accumbens and on the posterior half of the ventral pallidum. These brain regions are sensitive to opioids and endocannabinoids. Stimulation of other regions of the reward system increases wanting but does not increase liking and, in some cases, even decreases liking. The experience of pleasure also involves the orbitofrontal cortex. In humans, this region is activated by pleasant stimuli, including money, pleasant smells, and attractive faces.

Nucleus Accumbens

A region of the basal forebrain located in front of the preoptic region; brain region responsible for the emotion of Liking. The front shell of this is generally involved in appetitive behaviors, such as eating, and the back shell is generally involved in fearful defensive behaviors but depending on the emotions the sections may shift to include more or less of this area

Orbitofrontal Cortex

A region of the frontal lobes of the brain above the eye sockets; invloved in the experience of pleasure; this region is activated by pleasant stimuli

The Neural System of Freezing and Fleeing (Fear)

Fear is an unpleasant emotion that motivates avoidance of potentially harmful situations. Slight stimulation of fear-related brain areas causes animals to freeze, whereas intense stimulation causes them to flee.

Brain Regions Involved in the Fear System

The fear circuit extends from the central amygdala to the periaqueductal gray in the midbrain. These structures are sensitive to glutamate, corticotrophin-releasing factor, adreno-cortico-trophic hormone, and several different neuropeptides. Benzodiazepines and other tranquilizers inhibit activation in these areas. The role of the amygdala in fear responses has been extensively studied. Perhaps because fear is so important to survival, two pathways send signals to the amygdala from the sensory organs. When an individual sees a snake, for example, the sensory information travels from the eye to the thalamus and then to the visual cortex. The visual cortex sends the information on to the amygdala, provoking a fear response. However, the thalamus also quickly sends the information straight to the amygdala so that the organism can react before consciously perceiving the snake. The pathway from the thalamus to the amygdala is fast but less accurate than the slower pathway from the visual cortex. Damage to the amygdala or areas of the ventral hippocampus interferes with fear conditioning in both humans and nonhuman animals. Damage to the amygdala or areas of the ventral hippocampus interferes with fear conditioning in both humans and nonhuman animals.

Periaqueductal Gray

The gray matter in the midbrain near the cerebral aqueduct; part of the fear circuit

Amygdala

Almond-shaped neural structure that is primarily responsible for regulating emotional responses, especially fear

Thalamus

 A part of the diencephalon that works as a gateway for incoming and outgoing information; fear stimuli goes through here which either send it straight to the amygdala, or to the visual cortex and then the amygdala.

Visual Cortex

The part of the brain that processes visual information that is located at the back of the brain. For fear information will go to the thalamus, then here, then to the amygdala to  consciously perceiving the threat

The Circuits of Anger and Attack (Rage)

Anger or rage is an arousing, unpleasant emotion that motivates organisms to approach and attack. Anger can be evoked through goal frustration, physical pain, or physical restraint.

Brain Regions Involved in the Fear System

• The neural networks for anger and fear are near one another but separate. They extend from the medial amygdala, through specific parts of the hypothalamus, and into the periaqueductal gray of the midbrain. The anger circuits are linked to the appetitive circuits, such that lack of an anticipated reward can provoke rage. In addition, when humans are angered, they show increased left frontal cortical activation, supporting the idea that anger is an approach-related emotion (psychological and behavioral states that motivate an individual to move toward, engage with, or obtain a stimulus or goal). The neurotransmitters involved in rage are not yet well understood, but the neurotransmitter and neuromodulator Substance P (also involved in pain and stress) may play an important role. Other neurochemicals that may be involved in anger include testosterone and arginine-vasopressin. Several chemicals inhibit the rage system, including opioids and high doses of antipsychotics, such as chlorpromazine. 

The Neural System of Care and Attachment (Love)

For social animals such as humans, attachment to other members of the same species produces the positive emotions of attachment: love, warm feelings, and affection. The emotions that motivate nurturing behavior (e.g., maternal care) are distinguishable from those that motivate staying close to an attachment figure in order to receive care and protection (e.g., infant attachment).

Brain Regions Involved in the Love System

Important regions for maternal nurturing include the dorsal preoptic area (part of the anterior hypothalamus) and the bed nucleus of the stria terminalis (a band of fibers that runs along the top surface of the hypothalamus). These regions overlap with the areas involved in sexual desire and are sensitive to some of the same neurotransmitters, including oxytocin, arginine-vasopressin, and endogenous opioids (endorphins and enkephalins).

The Neural Network of Loneliness and Panic (Grief)

The neural networks involved in infant attachment are also sensitive to separation. These regions produce the painful emotions of grief, panic, and loneliness. When infant humans or other infant mammals are separated from their mothers, they produce distress vocalizations or crying. The attachment circuits are those that cause organisms to produce distress vocalizations when electrically stimulated.

Brain Regions Involved in the Grief System

The attachment system begins in the midbrain periaqueductal gray, very close to the area that produces physical pain responses, suggesting that it may have originated from the pain circuits. Separation distress can also be evoked by stimulating the dorsomedial thalamus, ventral septum, dorsal preoptic region, and areas in the bed nucleus of stria terminalis (near sexual and maternal circuits). These regions are sensitive to endogenous opiates, oxytocin, and prolactin. All of these neurotransmitters prevent separation distress. Opiate drugs such as morphine and heroin, as well as nicotine, artificially produce feelings of pleasure and gratification similar to those normally produced during positive social interactions. This may explain why these drugs are addictive. Panic attacks appear to be an intense form of separation distress triggered by the attachment system, and panic can be relieved by opiates. Testosterone also reduces separation distress, perhaps by reducing attachment needs. Consistent with this, panic attacks are more common in women than in men.