Section 10: Proving iPSC Pluripotency
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7 Terms
How do iPSCs morphologically resemble ESCs?
iPSCs morphologically resemble embryonic stem cells with similar colony shape and cell appearance.
Are iPSCs epigenetically reprogrammed?
Yes, iPSCs are epigenetically reprogrammed, meaning DNA and histone modifications are redistributed to resemble the ESC state.
Do iPSCs have similar gene expression to ESCs?
Yes, iPSCs have gene expression patterns that resemble embryonic stem cells, confirmed by microarray, RT-qPCR, and western blot.
What is the teratoma formation test?
Teratoma formation is a test where iPSCs are injected into mice to see if they form teratomas containing all three germ layers.
What is the gold standard for proving pluripotency?
The gold standard is showing iPSCs can contribute to a complete organism and differentiated tissues, including germline transmission.
What differentiation tests do iPSCs undergo?
iPSCs undergo in vitro differentiation to show they have the capacity to form different cell typ