platelet factors and others

PF 1

• Platelet Accelerator

• accelerates prothrombin conversion

PF 2

• Thrombin Accelerator

• facilitates the interaction of thrombin and fibrinogen hence the

  fibrinoplastic platelet factor

PF 3

• Phospholipid

• necessary for the generation of plasma thromboplastin (in vivo)

PF 4

• Heparin Inhibitor

• has anti-heparin activity; alpha granule

howell’s , Morawitz, Waterfall theory of breckenridge and ratnoff

Three theories of blood coagulation

Morawitz theory

howells theory

phase 1 the initiator (contact) reaction

Phase II thromboplastogenesis

phase III thrombogenesis

phase IV fibrin formation

Normal endothelial surface

Inhibitor of phase 1 the initiator (contact) region

Antithromboplastins

Inhibitor of phase II thromboplastogenesis

anti thrombin

inhibitor of phase III thrombogenesis

fibrinolysis

inhibitor of phase IV fibrin formation