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Normal
discharge
clear/ white
odorless
viscous/ sticky
symptoms
none
pathogen
normal flora
Vulvovaginal
Candidiasis (VVC) or
Yeast Infections
discharge
very thick & white, odorless
symptoms
itching, redness, edema
pathogen
fungal
Bacterial Vaginosis
(BV)** REFER
discharge
thin (watery), off-white or gray, fishy odor
symptoms
none
pathogen
bacterial
Trichomoniasis** REFER
discharge
yellow, frothy, malodorous
symptoms'
vaginal irritation, redness, edema
pathogen
parasite
Vulvovaginal Candidiasis (VVC)
a. Also known as a: yeast infection
b. Most common75% of women report one infection over their lifetime
c. Candida albicans is the most common pathogen
d. No single causative factor:
i. Pregnancy
ii. High dose combined oral contraceptives or estrogen therapy
iii. Sexually active
e. Symptoms:
i. Discharge
thick and white
odorless
ii. Other Signs
1. Itching
2. Redness
3. Edema (swelling)
Vulvovaginal Candidiasis (VVC)
treatment goals and exclusions
i. Goals
1. Relieve symptoms
2. Eradicate the infection
3. Reestablish normal flora
i. Self-treatment is appropriate in uncomplicated disease, infrequent episodes, and mild-moderate
symptoms (no foul odor, correct appearance)
1. **Doctor must have diagnosed a previous infection
iii. Exclusion to Self-Treatment
first yeast infection (2nd and on then can treat)
2. Recurrent infections at least 3 documented infections in one year
3. Fever or pain in the pelvic area
4. Pregnant
5. Younger than 12 years old
6. Reinfection within 2 months
Non pharm and pharm
Non-Pharmacologic
1. Nonabsorbent clothing (think breathable underwear)
2. YogurtLactobacillus
3. Limiting sucrose and refined carbohydrates
4. Discontinue any offending agent after consult with PCP (ex. antibiotics)
v. Pharmacologic
1. Imidazoles are first line; considered part of the antifungal pharmacologic class
2. Alters fungal cell membrane permeability; cause structural damage to fungal membranes
3. Come as tablets, creams, and suppositories → all patient specific
4. All equally effective just dependent on the treatment duration of 1, 3, or 7 days
a. 7 day treatment allows for smaller, less concentrated doses over an entire week
compared to a single potent dose with 1 day of therapy
Duration of therapy does not correspond to time of resolution
of symptoms
a. Miconazole (Monistat®)
b. Clotrimazole (Myclex®, Gyne-Lotrimin®)
c. Tioconazole (Vagistat®)
i. Only comes as a 1-day formulation
all resolves in a week
Adverse Effects uncommon, typically see with the first dose mimic symptoms of the
infection
.a. itching
b. Irritation
c. Vulvovaginal burning
7. Drug Interactions
a. Unlikely because limited absorption
Counseling Points
a. Prefer to administer therapy at bedtime to minimize leakage
b. Symptoms should improve within 2-3 days and resolution of infection within 1
week (ALL PRODUCTS: 1, 3, and 7)
c. Call physician if seeing no improvement or if symptoms worsen
d. Can use these antifungals during menstruation
Other Therapies/Complimentary Agents
1. Benzocaine products (i.e. Vagisil® cream)
→ bug bites, hemorrhoid, burns and wounds, vaginal itching
a. Relieve itching but does not address underlying cause
b. Add on therapy only for itching
c. Can be used for just itching alone and no VVC
Urinary Tract Infection (UTI)
. Need to differentiate between a yeast infection and a UTI when deciding if self-treatment is appropriate
b. Symptoms
i. Pain or burning when urinating; cloudy urine
ii. Need to urinate but having issues passing urine
iii. Frequent trips to the bathroom
c. Treatment
i. Non-Pharmacologic
1. Hydration with water to help flush bacteria out
2. Urinate after intercourse
3. Breathable underwearcotton
4. Avoid any irritants
5. Cranberry
a. Not for treatment
b. May have a role for prevention
i. Decrease the bacteria on the wall of the
membrane
ALWAYS REFER for antibiotic therapy
UTI Pharmacologic
1. ALWAYS refer to doctor for antibiotic therapy
a. Eradicate the infection
b. Stop possible progression to the kidneys
2. Symptom management only with OTC products:
a. Phenazopyridine (AZO® Maximum Strength or Uristat®)
i. Dose: 95 mg
ii. Directions: 2 tabs PO TID with meals for a maximum of 2 days
iii. Counseling:
Drink lots of water -flushes bacteria
2. May discolor urine/contact lenses/mucous membranes an orange
color -very brown/ red tablet
urine → bright red
b. AZO® Urinary Tract Defense® or Cystex®
i. Dose: Sodium salicylate (NSAID analgesic 162.5 mg) and methenamine → do not give if person has NSAID allergy
(antibacterial agent 162 mg)
ii. Directions: 2 tabs PO TID with meals for a maximum of 2 days
iii. Counseling:
1. Drink lots of water
does NOT discolor urine
Home Diagnostic Tests
a. UTI Tests
a. Early detection for patients with a history of recurrent UTIs
b. Confirmation of eradication following antibiotic therapy
c. Mechanism: detects nitrite & leukocyte esterase (found in urine when UTI is present)
Pregnancy test
1. Fertilization--produces human chorionic gonadotropin (hCG) hormone
2. Placenta produces hCG as early as 7 days after conception
3. hCG is excreted in the urine
4. Normal menstruation cycle – no hCG! Pregnancy hormones = HUGE spike in hCG!
5. Counseling = Follow package instructions!! Urinate directly on test stick vs. clean catch (cup)
6. Timing is everything: most accurate 1 week after first day of missed period
7. Use 1st morning urine because hCG most concentrated
8. Test immediately after collection & lay device on flat surface
Ovulation/Fertility Tests = Similar to pregnancy test
1. Detects changes in luteinizing hormone (LH) found in urine; LH spike = ovulation!
2. Testing should begin 2-4 days before the estimated day of ovulation
3. Test every day until LH is detected
4. Early morning detection is best (LH surges early in day)
5. Chances of conceiving are increased over next 48 hours