socrative: all about platelets

what laboratory test is used to measure the intrinsic pathway

PTT

what medication is used to monitor the intrinsic pathway

heparin

what lab test is used to monitor the extrinsic pathway

PT

what medication is used to monitor the extrinsic pathway

warfarin and coumadin

what factor is NOT dependent on vitamin K

VIII

which is NOT part of the cofactor group

protein C

what factor stabilizes the fibrin clot

XIII

which factor circulates bound to VWF

VIII

which factor is NOT part of the contact factor group

VIII

which of the following is a function of thrombin

all of the above

what factor is not part of the common pathway

VIII

what factor is NOT part of the intrinsic pathway

VII

what is the name of factor I

fibrinogen

what factor is deficient in hemophilia A

VIII

what serine protease digests the fibrin clot

plasmin

which is part of primary hemostasis

blood vessels

where are the procoagulants produced

liver

what vitamin is essential for normal synthesis of prothrombin group proteins, thus enabling them to bind to Ca2+

vitamin K

which is necessary for platelet aggregation

fibrinogen

which of the following is increased in DIC

all of the above

which patient group is most suceptible to bleeding because of a deficiency of vitamin k dependent proteins

newborns

clot based mixing studies and bethesda titers are used to test for

inhibitors

what factor deficiency causes hemophilia B

IX

what coagulation test is most sensitive for detecting mild liver disease

PT

what factor becomes deficient early in liver disease, and what assay does its deficiency prolong

factor VII deficiency, PT

what is the correct term to describe a platelet count of 550×10^9/L when all other CBC results are normal

thrombocytosis

A 28-year-old woman sees her family physician complaining of easy bruising and menorrhagia.nShe has a platelet count of 60 × 109/L. All other hematology and routine coagulation tests are normal. She has a platelet-associated immunoglobulin G (IgG) autoantibody in her serum. Which is most likely?

chronic ITP

which is a commonly used drug that can cause thrombocytopenia

heparin

what is the probable cause for TTP

Deficiency of a metalloprotease needed to enzymatically degrade unusually large von Willebrand factor (VWF) multimers

which patient group is most commonly diagnosed with acute ITP

children after having an infection

A 4-year-old child becomes very sick after drinking contaminated water. Kidney function tests are markedly elevated. Thrombocytopenia is mild, and a few schistocytes are noted on the blood film. Which is most likely the diagnosis?

HUS

binding of therapeutic heparin PF4 is used in testing to confirm

heparin induced thrombocytopenia

A patient in the intensive care unit has anemia, schistocytes, and thrombocytopenia. The PT and PTT are elevated, and the fibrinogen is low. What diagnostic test should be used?

D dimer to confirm acute DIC

Which is an autosomal recessive disorder in which the GP Ib/IXI/V complex is missing from the platelet surface?

bernard soulier syndrome

which is the most likely diagnosis for an infant who experiences bleeding after circumcision with epistaxis and gingival bleeding (early mucocutaneous bleeding)

glanzmann thrombasthenia

which is true regarding testing for the diagnosis of vascular disorders

most do not have abnormal clinical lab tests

patients with bernard soulier syndrome have which of the following laboratory test findings

abnormal platelet response to ristocetin

aspirin blocks the synthesis of

thromboxane A2

a defect in GP IIb/IIIa causes

glanzmann thrombasthenia

which disorders affects the adhesion of platelets

bernard soulier syndrome

which disorder affects the aggregation of platelets

glanzmann thrombasthenia

inappropriate formation of platelets or fibrin clots that obstructs blood vessels is called

thrombosis

a patient has a quantitative D dimer of 800 ng/mL. which can be ruled out from the following list

patient is normal

what is an expected finding in DIC

schistocytes on the blood flim

what tests should be performed on a regular basis on patients receiving therapeutic heparin

PTT and platelet count

A 37-year-old female patient has a PTT of 76 seconds (reference range, 25 to 37 seconds). Her plasma is mixed 1:1 with normal plasma. An immediate PTT performed on the mix is 74 seconds. Which is the most likely diagnosis?

lupus anticoagulant

why does the factor V leiden mutation increase thrombotic risk

makes factor Va resistant to degradation by activated protein C