Hematology Integrated Systems Practice Flashcards

Vocabulary-based flashcards covering key hematological syndromes, diagnostic markers, cell morphologies, and laboratory values mentioned in the lecture notes.

Hermansky Pudlak syndrome

A condition characterized by a deficiency in dense / delta granules.

Grey platelet syndrome

A condition characterized by a deficiency in Alfa granules.

MPO markers

Myeloperoxidase-associated markers including CD13, 33, and 117.

NSE markers

Non-specific esterase markers associated with monocytes, including CD14 and CD64.

Dohle bodies

Dilated Endoplasmic Reticulum (ER) seen as inclusions in White Blood Cells during toxic states.

LAP Score High

A finding associated with Leukemoid reaction.

Low LAP Score

A finding associated with Chronic Myeloid Leukemia (CML) and Paroxysmal Nocturnal Hemoglobinuria (PNH).

Codocytes

Target cells seen in Thalassemia, HbC, Asplenia, and Liver disease.

Drepanocytes

Sickle-shaped red blood cells characteristic of Sickle cell anemia.

Dacruocyte

Tear drop-shaped red blood cells seen in Myelofibrosis or Myelophthisis.

Echinocytes

Burr cells associated with burns, renal failure, and Pyruvate kinase deficiency.

Basophilic stippling

Ribosomal remnants in RBCs seen in Lead (Pb) poisoning.

Heinz bodies

Denatured Hb seen in G6PD deficiency, visualized with supravital stain.

Mentzer index

A calculation used to differentiate Iron Deficiency Anemia (IDA) from Thalassemia minor.

Ham’s acidified serum test

A confirmatory test used for Paroxysmal Nocturnal Hemoglobinuria (PNH).

TRAP+

Tartrate-resistant acid phosphatase positivity, a marker for Hairy Cell Leukemia.

Reed-Sternberg (RS) cells

Giant cells characteristic of Hodgkin Lymphoma; variants include Lacunar, Mononuclear, Mummified, and Popcorn cells.

CRAB acronym

Clinical features of Multiple Myeloma: Calcium elevation ($Ca > 11.5\,mg/dL$), Renal insufficiency, Anemia ($Hb < 10\,g/dL$), and Bone lesions.

TRALI

Transfusion Related Acute Lung Injury, presenting with dyspnea, hypoxemia, and bilateral chest infiltrates.

TACO

Transfusion Associated Circulatory Overload, presenting with dyspnea, edema, and a raised JVP.

TEG R value

Reaction Time ($5\text{--}10\,min$) measuring clotting factors; and increased value indicates deficiency.

Lavender Vacutainer

Contains EDTA; used for CBC, ESR (Wintrobe), and HbA1c.

Grey Vacutainer

Contains Potassium oxalate and Sodium fluoride (NaF) for glucose estimation and alcohol testing.

Blue Vacutainer

Contains $3.2\%$ Sodium citrate; used for coagulation studies like aPTT and PT.

Aquagenic pruritus

Severe itching after water exposure, characteristic of Polycythemia vera.