IgG Classes and Subclasses (Meng)

What are the Fc receptors that match each function?

-______________: opsonization; ADCC

-______________: placenta transport

-______________: allergic reactions

-FcyR

-FcRn

-FcER

What does ADCC stand for?

Antibody dependent cytotoxicity

What type of bond is holding together the heavy and light chains of antibodies?

Disulfide bonds

All IgG subclasses can cross the placenta via ____________ _____ receptors

neonatal Fc (FcRn)

__________ are the primary antibody response to protein antigens, and the most abundant gamma subclass in the blood

IgG1s

Which IgG subclass is critical for response to infections from polysaccharides?

IgG2

Which IgG subclass has the shortest half life in blood circulation?

IgG3

Which IgG subclass does not exhibit direct killing functions due to lacking sufficient ADCC activities?

IgG4

True or False: all of the IgG subclasses are capable of crossing the placenta via neonatal receptors

True

_______ antibodies are most abundant in serum

IgG

_________ antibodies are important for allergic reactions

IgE

Which antibody class exists as a doublet?

IgA

Which antibody class exists as a pentamer?

IgM

Which antibody class is most effective in activating the complement cascade?

IgG

Which antibody class is most effective in activating neutrophils and natural killer cells?

IgG

Which antibody class is most effective in activating basophils and mast cells?

IgE

Which IgG subclass is known to activate both ADCC and complement?

IgG1

Which IgG subclass has the shortest half life in blood circulation?

IgG3

Which IgG subclass preferentially targets polysaccharide antigens?

IgG2