(F) CC2 Lec L1

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Marijuana

Window of Detection in Urine:

• 2 days - 3 weeks

Initial Screening Cut-off (ng/dL):

• 50

Confirmatory Cut-off (ng/dL):

• 15

Cocaine

Window of Detection in Urine:

• 2 - 3 days

Initial Screening Cut-off (ng/dL):

• 300

Confirmatory Cut-off (ng/dL):

• 150

Opiates

Window of Detection in Urine:

• 2 - 3 days

Initial Screening Cut-off (ng/dL):

• 2000

Confirmatory Cut-off (ng/dL):

• 2000

Amphetamine

Window of Detection in Urine:

• 2 - 3 days

Initial Screening Cut-off (ng/dL):

• 1000

Confirmatory Cut-off (ng/dL):

• 250

Methamphetamine

Window of Detection in Urine:

• 2 - 3 days

Initial Screening Cut-off (ng/dL):

• 500

Confirmatory Cut-off (ng/dL):

• 250

PCP (Phencyclidine)

Window of Detection in Urine:

• 8 days - 3 weeks

Initial Screening Cut-off (ng/dL):

• 25

Confirmatory Cut-off (ng/dL):

• 25

Benzodiazepines

Window of Detection in Urine:

• 3 or more days

Initial Screening Cut-off (ng/dL):

• 300

Confirmatory Cut-off (ng/dL):

• 300

A

What refers to the policy of the State aimed at safeguarding its citizenry from the harmful effects of dangerous drugs?

• a. Republic Act No. 9165

• b. Chain of Custody

• c. Custody and Control Form

• d. Confirmatory Drug Testing

• e. Specimen Validity Testing

C

Which two substances are considered the top predominantly abused drugs in the Philippines?

• a. Amphetamines and Methamphetamines

• b. Benzodiazepines and Barbiturates

• c. Marijuana and Shabu

• d. Morphine and Codeine

• e. Hydromorphone and Oxycodone

B

Who strictly supervises and operates a Confirmatory Drug Testing Laboratory (CDTL)?

• a. Registered Medical Technologist

• b. Registered Chemist

• c. Authorized Specimen Collector

• d. Drug Test Analyst

• e. Head of the Laboratory

C

Which drug is therapeutically used for the treatment of narcolepsy and Attention-Deficit Hyperactivity Disorder (ADHD)?

• a. Methamphetamine

• b. MDMA

• c. Amphetamines

• d. Cocaine

• e. Phencyclidine

E

What is the active composition of the street drug known as "Shabu"?

• a. 57% Cannabis sativa

• b. Enzyme-Linked Immunosorbent Assay

• c. Benzoylecgonine

• d. Tetrahydrocannabinol

• e. 35% Methamphetamine Hydrochloride

A

Which toxic effect is a distinct characteristic of MDMA (Ecstasy)?

• a. Stiffening of arms, legs, and jaw

• b. Severe teeth grinding (bruxism)

• c. Impairment of short-term memory

• d. Severe hypertension and arrhythmias

• e. Testicular atrophy

C

What is the most active psychoactive component of marijuana?

• a. Benzoylecgonine

• b. Ephedrine

• c. Tetrahydrocannabinol (THC)

• d. Phencyclidine

• e. Secobarbital

A

What is the primary urine metabolite for Cocaine that acts as a high-yield target for drug panels?

• a. Benzoylecgonine

• b. Codeine

• c. Morphine

• d. Methadone

• e. Fentanyl

D

What is the clinical therapeutic use of Cocaine?

• a. Treatment of narcolepsy

• b. Powerful analgesic and sedative

• c. Treatment for male hypogonadism

• d. Local anesthetic for nasopharyngeal surgery

• e. Treatment for Attention-Deficit Hyperactivity Disorder

C

Which of the following is considered a naturally occurring opiate?

• a. Heroin

• b. Oxycodone

• c. Morphine

• d. Meperidine

• e. Fentanyl

B

Which drug has a highly lipophilic property that allows it to distribute rapidly into adipose and brain tissue?

• a. Cocaine

• b. Phencyclidine (PCP)

• c. Tetrahydrocannabinol (THC)

• d. MDMA

• e. Diazepam

D

Which of the following drugs falls under the Benzodiazepine classification?

• a. Secobarbital

• b. Pentobarbital

• c. Phenobarbital

• d. Lorazepam

• e. Meperidine

C

Which of the following can cause toxic hepatitis, accelerated atherosclerosis, and testicular atrophy when illicitly abused?

• a. Opiates

• b. Sedative-Hypnotics

• c. Anabolic Steroids

• d. Amphetamines

• e. Phencyclidine

A

What form provides complete documentation of a specimen's handling to maintain the Chain of Custody?

• a. Custody and Control Form

• b. Tamper-evident seal

• c. Result window

• d. Screening Drug Testing Form

• e. Rapid Diagnostic Test Form

C

What is the required volume for a urine drug test specimen?

• a. At least 5 mL

• b. Exactly 10 mL

• c. At least 60 mL

• d. Exactly 2 drops

• e. At least 1 cm

A

What is the strictly acceptable temperature range for a urine specimen within 5 minutes of collection?

• a. 32.5-37.7°C

• b. 4.5-8.0

• c. 1.002-1.020

• d. 35%

• e. 57%

D

Which alternative specimen is considered excellent for evaluating a chronic drug user?

• a. Urine

• b. Blood

• c. Sweat

• d. Scalp Hair

• e. Saliva

C

What is the strict collection requirement for a blood specimen in drug testing?

• a. 60 mL sterile clean-catch midstream

• b. Cut 1 cm above the scalp

• c. 5 mL drawn into a 10 mL plain tube strictly without anticoagulant

• d. Sweat patch applied to the upper arm

• e. 2 drops squeezed into the sample well

D

What is the laboratory retention policy for a specimen yielding a negative result?

• a. Minimum of 15 days

• b. Maximum of 1 year

• c. Exactly 5 minutes

• d. Minimum of 5 days

• e. 2 to 3 days

C

Which of the following circumstances triggers a Non-Correctable Rejection for a specimen?

• a. Failure of the ASC to sign the CCF

• b. Failure to record the specimen temperature

• c. Broken or tampered seal

• d. Appropriate remarks added

• e. Acceptable temperature range

B

What physiological waste product is measured to biochemically confirm if the specimen is actual human urine?

• a. Nitrites

• b. Creatinine

• c. Specific gravity

• d. pH

• e. Oxidizing adulterants

A

A drug testing specimen with a Nitrite level of ≥ 500µg/L is categorically classified as a/an:

• a. Adulterated Specimen

• b. Substituted Specimen

• c. Diluted Specimen

• d. Negative Result

• e. Invalid Result

B

A specimen is officially considered substituted when the specific gravity is:

• a. <1.003

• b. Strictly <1.002 or ≥1.020

• c. Exactly 1.000

• d. Between 4.5-8.0

• e. ≥11

D

What specific validity criteria defines a diluted specimen?

• a. Creatinine <442.0µmol/L

• b. Nitrite ≥500µg/L

• c. pH <3 or ≥11

• d. Creatinine <1768.0µmol/L and Specific gravity <1.003

• e. Specific gravity strictly <1.002 or ≥1.020

D

Which immunoassay screening method uniquely utilizes radioisotopes to tag antibodies?

• a. Enzyme Immunoassay (EIA)

• b. Enzyme Multiplied Immunoassay Technique (EMIT)

• c. Fluorescence Polarization Immunoassay (FPIA)

• d. Radioimmunoassay (RIA)

• e. Chemiluminescence

A

In Gas Chromatography-Mass Spectrometry (GC-MS), the GC component specifically separates analytes based on their:

• a. Volatility

• b. Specific gravity

• c. Antibody-antigen reactions

• d. pH levels

• e. Lipophilic property

C

Which analytical technique drastically enhances trace element detection capability through the use of a second mass spectrometer?

• a. High-Performance Liquid Chromatography

• b. Thin Layer Chromatography

• c. Tandem Mass Spectrometry

• d. Gas Chromatography-Mass Spectrometry

• e. Liquid Chromatography-Mass Spectrometry

B

Exactly how many drops of urine are required to be squeezed into the sample well of a rapid drug test kit?

• a. 5 drops

• b. Exactly 2 drops

• c. 1 cm

• d. At least 60 drops

• e. 5 mL

E

What is the interpretation when only one purple band appears in the Control (C) region and NO line appears in the Test (T) region of a rapid kit?

• a. Negative Result

• b. Substituted Specimen

• c. Invalid Result

• d. Diluted Specimen

• e. Positive Result

E

What major downside of urine testing can cause a false-negative result in chronic drug abusers who temporarily stop using?

• a. Competitive Immunoassay

• b. Hyphenated Techniques

• c. Chain of Custody

• d. Exogenous substance

• e. Window of detection

Republic Act No. 9165

The legal policy enacted to safeguard the citizenry from the harmful effects of dangerous drugs, also known as the Comprehensive Dangerous Drugs Act of 2002.

Drugs of Abuse

Any non-medical use of legally available or illegal substances that causes physical, psychological, legal, economic, or social damage to the user.

Screening Drug Testing Laboratory (SDTL)

The laboratory tier that performs initial tests utilizing Rapid Diagnostic Test (RDT) kits and Enzyme-Linked Immunosorbent Assay (ELISA).

Bruxism

A prominent toxic effect of amphetamines characterized by severe teeth grinding.

MDMA (3,4-methylenedioxymethamphetamine) / Ecstasy

A highly popular recreational designer drug, derived from methamphetamine, which commonly causes stiffening of the arms, legs, and jaw.

Cannabis sativa L. (Indian Hemp)

The specific botanical source from which street marijuana is derived.

Tetrahydrocannabinol (THC)

The most active psychoactive component of marijuana which causes short-term memory impairment.

Coca bush

The plant source from which cocaine is derived.

Benzoylecgonine

The primary urine metabolite of cocaine that acts as the high-yield target for standard drug panels.

Opiates (Narcotics)

Chemicals derived directly from the opium poppy that serve as powerful analgesics, sedatives, and anesthesia agents.

Heroin

A chemically modified opiate alongside Hydromorphone and Oxycodone.

Phencyclidine (PCP)

A unique drug that distributes rapidly into adipose and brain tissue due to its highly lipophilic property.

Barbiturates

A sedative-hypnotic classification that includes secobarbital, pentobarbital, and phenobarbital.

Anabolic Steroids

Substances used clinically to treat male hypogonadism but illicitly abused by athletes to rapidly improve muscle mass, leading to testicular atrophy.

Custody and Control Form (CCF)

The form that provides complete documentation of a specimen's handling to maintain the Chain of Custody.

Authorized Specimen Collector (ASC)

The designated personnel who prepares supplies, verifies donor identification, and observes the specimen collection process.

Sterile, clean-catch midstream collection

The collection technique mandated for urine specimens to prevent contamination.

Within 5 minutes

The precise timeframe within which the ASC must measure the specimen temperature after it has been collected.

Scalp Hair

The specimen type collected by cutting 1 cm above the scalp, which is heavily utilized for evaluating a chronic drug user.

1 year

The maximum duration a positive drug test specimen can be retained upon a formal request.

Non-Correctable Rejection

The rejection category applied to specimens possessing incompatible ID numbers or a broken/tampered seal.

Validity Testing

The testing procedure implemented to ensure specimen integrity by examining physical parameters and biochemical markers.

Creatinine

A physiological waste product continuously cleared by the body that is measured to confirm if the submitted specimen is actual human urine.

Adulterated Specimen

The category of an invalid specimen wherein the donor adds an exogenous substance such as household bleach.

Substituted Specimen

The category of an invalid specimen indicated by a creatinine level of strictly <442.0µmol/L.

Diluted Specimen

The category of an invalid specimen marked by a creatinine level of <1768.0µmol/L coupled with a specific gravity of <1.003.

Immunoassays

Highly sensitive screening tests that utilize antibody-antigen reactions to detect small amounts of a drug or its metabolites.

Liquid Chromatography-Mass Spectrometry (LC-MS)

A confirmatory analytical technique heavily combining the separation power of liquid chromatography with the high sensitivity of mass spectrometry.

Exactly 5 minutes

The exact time constraint placed on interpreting the results of a rapid drug testing kit.

Negative Result

The result interpretation derived when two purple bands appear on the rapid kit, consisting of one in the Control (C) region and one in the Test (T) region.