D+D Skin Final (Med Chem Structures) (4th Year Fall 2026)

Calcipotriene (Dovonex Cream) (Vitamin D3 analog)

ATRA (Tretinoin)

Isotretinoin (13-cis retinoic acid)

Tazarotene (Tazorac Gel 0.05% or 0.1%)

Tazarotenic Acid (active metabolite for Tazarotene)

Etretinate (Tegison)

Acitretin (Soriatane) (active metabolite of Etretinate)

Anthralin (Psoriatec 1% Cream)

Tapinarof (Vtama 1% Cream)

Resveratrol

Methoxsalen (Psoralen, Oxsoralen-Ultra, Oral)

Mono Adducts/Thymine DNA Strand

Apremilast (Otezla)

Alefacept (Amevive) BIOLOGIC

fusion binds to CD2 on T cells, blocks T cell activation, IM

Efalizumab (Raptiva) BIOLOGIC

mAb targets LFA1 on T cells, blocks T cell activation, SQ

Ixekizumab (Taltz) BIOLOGIC

inhibits IL-17A (pro inflammatory cytokine), inhibits skin cell proliferation and inflammation, autoinjector, indicated for moderate to severe plaque psoriasis

Ustekinumab (Stelara) BIOLOGIC

inhibits both IL-12 and IL-23 signaling by binding to the p40 subunit of both cytokines, SQ, for plaque psoriasis and psoriatic arthritis

Deucravacitinib (Sotyktu)

Tyrosine Kinase 2 (Tyk2) inhibition leads to blockade of IL-12 and IL-23 signaling