heme exam 2

The membrane protein that transports Fe++ out of the enterocyte or the macrophage is 

ferroportin

The first test that would be out of range if a person is beginning to become iron deficient would be the

ferritin

if someone has anemia and a below reference range reticulocyte count, what is that indicative of?

proliferation disorder

In a microcytic anemia, which RBC index would always be low?

mcv

In which of the microcytic hypochromic anemias is the ferritin low and the TIBC high?

IDA

In Anemia of Inflammation, which of the following prevents iron release from a cell?

hepcidin

What stain is used to detect iron deposits in a cell?

prussian blue

What is the first iron profile test to become abnormal when a patient is developing iron deficiency?

ferritin

What is the most immediate danger in traumatic acute blood loss?

volume collapse/ shock

In chronic blood loss, when does the patient usually become anemic?

when they beome iron deficient

In acute blood loss, when does their hemoglobin test indicate anemia?

once total blood volume has been restored

A defect in heme synthesis results in what anemia?

porphyria

Thalassemia involves a genetic error resulting in:

insufficient globin synthesis

In Hemoglobin H disease, ____ of the four _____ chains are affected

Three/alpha

Hemoglobin Barts consists of 

Four gamma chains

In beta thalassemia trait, the red blood cell count is usually__________ and the RBCs are ___________

normal to increase/ microcytic

true or false the determination wjether a macrocytic anemia is megaloblastic or nonmegaloblastic is based on the MCV

false

a possible cause of a non megaloblastic macrocytic anemia is

alcoholism

a b12 deficiency results in

errors in dna formation

pernicious anemia is caused by

autoantibodies to IF and gastric cells

what are some phyical signs of anemia

fatigue shortness of breath skin pallor tachycardia

what are some physiological adaptations to anemia

increased erythropoesis by the BM to compensate for dec rbc surival or rbc mass

what are the three morphological classifications of anemia

micro normo and macro cytic

what are 3 pathophysiological classifications of anemia

impaired rbc production (ineffective erythropoesis/ maturation defect)

insufficenr rbc production (hypoproliferation)

increased RBC destruction (hemolysis)

blood loss

diiferentiate betwee acute blood loss and chronic blood loss w/ regards to CBC

acute: hgb and hct dont fall immediately, mcv mchc mch initally normal, neutrophilic leukocytosis w/ left shift, initial platelet decrease followed by increase, increased retic after 3-5days, transient macrocytosis from reticulocytosis

chronic: anemia develops AFTER iron strores are depleted, eventuslly become microcytic hypochromic, wbc normal or slightly dec, platelets commonly inc, retic count normal/ sloghtly inc

what are the four major microcytic anemias and what part of the hgb molecule is impaired

ida- iron

aoi- iron avaliability/utilization

sideroblastic- heme synthesis/ iron incorperation

thalassemia - globin chain synthesis

what is the journey of iron from the time its consumed until the time it is made avaliable for erythtopoesis