gene/syndrom/locus/cancer

MYH

1p23 | Syndrome: MYH polyposis | Inheritance: AR (The ONLY Recessive exception!) | Main Cancers: Colorectal

hMSH2

2p15-16 | Syndrome: Lynch syndrome, Muir-Torré syndrome, Turcot | Main Cancers: Colorectal, endometrial, urinary tract, ovarian, gastric, small bowel, brain, sebaceous tumors, laryngeal

hMLH1

3p21 | Syndrome: Lynch syndrome, Turcot | | Main Cancers: Colorectal, endometrial, urinary tract, ovarian, gastric,

hMSH6

2p16 | Syndrome: Lynch syndrome 1 | Inheritance: AD | Main Cancers: Colorectal, endometrial, urinary tract, ovarian, gastric, small bowel, hepatobiliary

hPMS1

2q31 | Syndrome: Lynch syndrome 2 | Main Cancers: Colorectal, endometrial, urinary tract, ovarian, gastric,

hPMS2

7p22 | Syndrome: Lynch syndrome 2 | Main Cancers: Colorectal, endometrial, urinary tract, ovarian, gastric, small bowel, hepatobiliary

TACSTD1

2p21 | Syndrome: Lynch syndrome | upstream of msh2

APC

5q21 | Syndrome: Familial adenomatous polyposis, Turcot syndrome | Main Cancers: Colorectal, duodenal, thyroid, brain

SMAD4 / DPC4

18q21.1 | Syndrome: Juvenile polyposis | Main Cancers: Colorectal

BMPR1A

10q22 | Syndrome: Juvenile polyposis | Main Cancers: Colorectal

RET

10q11.2 | Syndrome: Multiple Endocrine Neoplasia Type II (MEN2) | Main Cancers: Thyroid (medullary), pheochromocytoma

PTEN

10q23 | Syndrome: Cowden disease, multiple hamartoma syndrome | Main Cancers: Breast (females), thyroid (papillary), testicular (seminoma)

MEN1

11q13 | Syndrome: Multiple Endocrine Neoplasia Type I (MEN1) | Main Cancers: Parathyroid, thyroid, anterior pituitary, pancreatic islet cells,

TP53

17p13 | Syndrome: Li-Fraumeni syndrome | Main Cancers: Sarcoma, breast, brain, leukemia, adrenal cortex

BRCA1

17q21 | Syndrome: Breast/ovary families | Main Cancers: Breast, ovary, colon, prostate

BRCA2

13q12 | Syndrome: Breast (+ ovary) families | Main Cancers: Breast, ovary

RB1

13q14 | Syndrome: Familial retinoblastoma | Main Cancers: Retinoblastoma

STK11

19p13.3 | Syndrome: Peutz-Jegher syndrome | Main Cancers: Gastrointestinal, breast, uterus, ovary, testis

PTCH

9q22 | Syndrome: Gorlin (nevoid basal cell carcinoma) syndrome | Main Cancers: Basal cell carcinomas, medulloblastoma, ovarian fibromas, odontogenic keratocysts

VHL

3p25-26 | Syndrome: von Hippel-Lindau disease | Main Cancers: CNS hemangioblastoma, renal, pancreatic, pheochromocytoma

FLCN

17p11.2 | Syndrome: Birt-Hogg-Dubé syndrome | Inheritance: AD | Main Cancers: Renal

CMM1

1p | Syndrome: Dysplastic nevus syndrome | Main Cancers: Melanoma (familial atypical mole melanoma, FAMM)

EMSY

سرطان پستان
BRCA1 17q BRCA2 13q -

OPCML

ﺳﺮﻃﺎن ﺗﺨﻤﺪان
11q25
LOH

HPC1

1q11
ﺳﺮﻃﺎن ﭘﺮوﺳﺘﺎت

HPC2

ﺳﺮﻃﺎن ﭘﺮوﺳﺘﺎت

ELAC2

17p11
ﺳﺮﻃﺎن ﭘﺮوﺳﺘﺎت

PTEN, MXI1, KAI1

ﺳﺮﻃﺎن ﭘﺮوﺳﺘﺎت نادرتر

C-MYC

t(8q,14q)
heavy chain imonoglubin locus
90% Burkeit lanphom^


t(8,2) Kappa light Chain
t(8,22) lambda light chain

MERCATOR

Uses only coding exons as initial anchoring points