The rest of the Top 300 Drug class and BBW

Dorzolamide ophthalmic (Trusport)

Dorzolamide ophthalmic (Trusport)

Carbonic anhydrase inhibitor

Brimonidine ophthalmic (Alphagan P)

Alpha agonist

Timolol ophthalmic (Betimol, Timoptic)

Beta blocker, nonspecific (b1 + b2)

Latanprost ophthalmic (Xalatan)

Prostaglandin analog

Pioglitazone (Actos)

Thiazolidinediones (TZDs)

May cause or worsen CHF

Metformin + sitagliptin (Janumet)

Biguanide + DPP4-I

May cause lactic acidosis

Canagliflozin (Invokana)

SGLT2i

Increased risk of lower limb amputation

Insulin glargine (Lantus, Basaglar, Toujeo)

Long acting insulin

Insulin degludec (Tresiba)

Long acting insulin

Insulin aspart (NovoLog)

Fast acting insulin

Dulaglutide (Trulicity)

GLP-1 RA

Thyroid C-Cell tumor risk

Glimepiride (Amaryl)

Sulfonylureas

Insulin lispro (Humalog)

Short acting insulin

Liraglutide (Victoza)

GLP-1 RA

CI in patients with certain thyroid or endocrine cancers

Sitagliptin (Januvia)

DPP4i

Glipizide (Glucotrol)

Sulfonylurea

Linagliptin (Tradjenta)

DPP4i

Insulin detemir (Levemir)

Long acting insulin

Metformin (Glucophage)

Biguanide

May cause lactic acidosis

Acyclovir (Zovirax, Sitavig)

Antiviral, purine nucleoside

Cefdinir (Omnicef)

3rd gen cephalosporin

Valacyclovir (Valtrex)

Antiviral

Hydroxychloroquine (Plaquenil)

Disease modifying antirheumatic drug (DMARD)

Prescriber must be familiar with complete prescribing guidelines before use

Clindamycin (Cleocin)

Lincosamide

Risk of severe diarrhea and C. Diff

Fluconazole (Diflucan)

Triazole antifungal

Levofloxacin

Fluoroquinolone antibiotic

May increases risk of tendonitis and tendon ruptures especially in elderly

Mupirocin (Centany)

Topical antibiotic

Nitrofurantoin (Furdantin, Macrodantin, Macrobid)

Imidazolidinedione

Metronidazole (Flagyl)

Nitroimidazole 1st gen

Carcinogenic in mice - avoid necessary use

Amoxicillin (Amoxil, Moxatag)

Penicillin antibiotic (beta-lactam)

Azithromycin (Zithromax)

Macrolide antibiotic

Doxycycline (Doryx, Monodox, Periostat, Vibramycin)

Tetracycline antibiotic

Risk of severe diarrhea and C. Diff

Cephalexin (Keflex)

1st gen cephalosporin

Amoxicillin + Clavulanate (Augmentin)

Penicillin antibiotic (beta-lactam)

Oseltamivir (Tamiflu)

Antiviral, influenza

Ciprofloxacin (Cipro)

Fluoroquinolone antibiotic

May increase risk of tendonitis and tendon ruptures especially in the elderly

Sulfamethoxazole + trimethoprim (Bactrim, Septra, Sulfatrim)

Sulfonamide antibiotic

Minocycline (Minocin, Solodyn)

Tetracycline antibiotic

Ketoconazole (Nizoral, Extina, Xolegel)

Antifungals

Do not use unless other drugs do not work, severe hepatotoxicity, heart arrhythmias, and severe drug interactions

Cyanocobalamin (Vitamin B12)

Vitamin B12

Potassium Chloride (Klor-Con, Micro-K)

Electrolytes

Vitamin D (ergocalciferol [D2], cholecalciferol [D3])

Vitamin D

Ferrous sulfate (Feosol, Fer-in-Sol, Slow FE, Feratab)

Iron supplement

Folic acid

Vitamin B9

Albuterol + ipratropium (Combivent Respimat, DuoNeb)

Beta 2 agonist, short acting (SABA) + muscarinic antagonist, short acting (SAMA)

Budesonide inhaled (Pulmicort Respules/Flexhaler)

Inhaled Corticosteroid

Levoceterizine (Xyzal)

2nd generation antihistamine

Albuterol inhaled (Proventil HFA, Ventolin HFA, Proair HFA)

Short acting beta-2 agonists (SABA)

Montelukast (Singulair)

Leukotriene inhibitor

Serious neuropsych events. Including agitation, aggression, depression, hallucinations, suicidal thoughts, etc.

Fluticasone inhaled (Flovent Diskus/HFA)

Inhaled corticosteroid

Cetirizine (Zyrtec)

2nd gen antihistamine

Budesonide + formoterol inhaled (Symbicort)

Long acting beta-2 agonist (LABA) + corticosteroid

Fluticasone + salmeterol inhaled (Advair Diskus/HFA, Wixela)

Long acting beta-2 agonist (LABA) + corticosteroid

Loratadine (Claritin)

2nd gen antihistamine

Tiotropium inhaled (Spiriva HandiHaler/Respimat)

Long acting muscarinic antagonist (LAMA)

Benzonatate (Tessalon)

Antitussive, non-narcotic

Tamsulosin (Flomax)

Alpha-1 receptor antagonist

Finasteride (Proscar, Propecia)

5-alpha-reductase inhibitor

Oxybutynin (Ditropan XL)

Antispasmodic, urinary

Prednisone (Sterapred)

Corticosteroid

Levothyroxine (Synthroid, Levoxyl, Levothroid)

Thyroid hormone

Not to be used for weight loss

Thyroid (Armour thyroid, Nature-Thyroid, Westhroid)

Natural thyroid hormone

Not to be used for weight loss

Testosterone topical (Androgel, Androderm, Axiron, Fortesta)

Testosterone hormone

Children should avoid contact with unwashed or unclothed application sites

Progesterone (Prometrium, Crinone, Procheive, Endometrin)

Progestion, non-contraceptive

Do not use in CV disease or dementia. Increased risk of breast cancer

Norethindrone (Camila, Errin, Jolivette)

Oral contraceptive, progestin only

Cigarette smoking increases the risk of MI and stroke

Liothyronine (Cytomel, Triostat)

Thyroid hormone

Not to be used for weight loss

Ethinyl estradiol + norethindrone (Junel, Loestrin)

Oral birth control

Cigarette smoking increases the risk of serious CV side effects. Increases with age over 35.

Estradiol (Estrace)

Estrogen hormone replacement

May increase the risk of endometrial cancer, stroke, MI, and breast cancer - May increase the risk of dementia in post menopausal women

Ethinyl estradiol + etonogestrel (NuvaRing)

Intrauterine/vaginal contraceptive

Cigarette smoking increases the risk of serious CV side effects. Increases with age over 35

Ethinyl estradiol + desogestrel (Apri, Enskyce)

Oral birth control

Cigarette smoking increases the risk of serious CV side effects. Increases with age over 35

Ethinyl estradiol + norgestimate (Sprintec, Tri-Sprintec)

Oral birth control

Cigarette smoking increases the risk of serious CV side effects. Increases with age over 35

Ethinyl estradiol + levonorgestrel (Amethyst, Aviane, Falmina)

Oral birth control

Cigarette smoking increases the risk of serious CV side effects. Increases with age over 35

Alendronate (Fosamax)

Bisphosphonate

Methylprednisolone (Medrol)

Corticosteroid

Hydrocortisone (Cortef, Cortizone, Hytone, Cortenema, Proctocort)

Corticosteroid

Prednisolone (Orapred, Pediapred)

Corticosteroid

Triamcinolone topical (Kenalog)

Topical corticosteroid

Adalimumab (Humira)

TNF inhibitor

Increased risk of serious infections. Lymphoma or other malignancies may also occur.

Methotrexate (Otrexup, Rasuvo, Trexall)

Antimetabolites, folate analog

Only for severe disease. Fetal death/birth defects. Impaired drug elimination. Hepatotoxicity. Pulmonary toxicity. Malignant lymphoma. Skin reactions

Dicyclomine (Bentyl)

Anticholinergic

Polyethylene glycol (MiraLax, GlycoLax)

Osmotic laxative

Docusate (Colace [sodium], Surfak [calcium])

Emollient laxative

Ondansetron (Zofran)

5HT3 RA

Promethazine (Phenergan)

1st gen antihistamine

CI in pts <2 years old - injection can cause severe tissues damage; caution advised

Pantoprazole (Protonix)

PPI

Omeprazole (Prilosec)

PPI

Esomeprazole (Nexium)

PPI

Famotidine (Pepcid)

H2 blocker

Ibuprofen (Advil, Motrin)

NSAID

May increase risk of CV thrombotic events - May increase risk of fatal GI events

Meloxicam (Mobic)

NSAID

May increase risk of CV thrombotic events - May increase risk of fatal GI events

Naproxen (Naprosyn, Naprelan)

NSAID

May increase risk of CV thrombotic events - May increase risk of fatal GI events

Celecoxib (Celebrex)

COX-2 inhibitor (NSAID)

May increase risk of CV thrombotic events - May increase risk of fatal GI events

Diclofenac (Voltaren)

NSAID

May increase risk of CV thrombotic events - May increase risk of fatal GI events

Ketorolac (Toradol, Sprix)

NSAID

Oral - up to 5 days of treatment and only after parenteral use

All - May increase risk of CV thrombotic events - May increase risk of fatal GI events

Tramadol (Ultram, ConZip, Qdolo)

Opioid agonist

High addiction/misuse risk

Opioid analgesic REMS

Life threatening respiratory depression can occur

Concomitant use with BZD

Morphine sulfate (Kadian, Morphabond, MS Contin)

Opioid agonist

High abuse potential - May lead to dependency and respiratory depression may occur even at accepted dosing - Adverse CV events and death reported on misuse

Hydrocodone + APAP (Norco, Lotab)

Opioid combo + non-narcotic

Avoid doses of APAP >4000mg per day (associated with cases of acute liver failure)

Oxycodone (OxyContin, Roxicodone, Xtampza ER)

Opioid agonist

High addiction/misuse risk

Opioid analgesic REMs

Life threatening respiratory depression can occur

Concomitant use with BZD

Butalbital + APAP (Fioricet, Alizital, Bupap, Phrenilin)

Pain reliever and relaxant combination

Avoid doses of APAP >4000mg per day (Associated with cases of acute liver failure)

Colchicine (Colcrys, Mitigare, Gloperba)

Anti-gout