\ Increased risk of serious infections. Lymphoma or other malignancies may also occur.
79
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Methotrexate (Otrexup, Rasuvo, Trexall)
Antimetabolites, folate analog
\ Only for severe disease. Fetal death/birth defects. Impaired drug elimination. Hepatotoxicity. Pulmonary toxicity. Malignant lymphoma. Skin reactions
80
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Dicyclomine (Bentyl)
Anticholinergic
81
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Polyethylene glycol (MiraLax, GlycoLax)
Osmotic laxative
82
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Docusate (Colace \[sodium\], Surfak \[calcium\])
Emollient laxative
83
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Ondansetron (Zofran)
5HT3 RA
84
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Promethazine (Phenergan)
1st gen antihistamine
\ CI in pts
85
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Pantoprazole (Protonix)
PPI
86
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Omeprazole (Prilosec)
PPI
87
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Esomeprazole (Nexium)
PPI
88
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Famotidine (Pepcid)
H2 blocker
89
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Ibuprofen (Advil, Motrin)
NSAID
\ May increase risk of CV thrombotic events - May increase risk of fatal GI events
90
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Meloxicam (Mobic)
NSAID
\ May increase risk of CV thrombotic events - May increase risk of fatal GI events
91
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Naproxen (Naprosyn, Naprelan)
NSAID
\ May increase risk of CV thrombotic events - May increase risk of fatal GI events
92
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Celecoxib (Celebrex)
COX-2 inhibitor (NSAID)
\ May increase risk of CV thrombotic events - May increase risk of fatal GI events
93
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Diclofenac (Voltaren)
NSAID
\ May increase risk of CV thrombotic events - May increase risk of fatal GI events
94
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Ketorolac (Toradol, Sprix)
NSAID
\ Oral - up to 5 days of treatment and only after parenteral use
All - May increase risk of CV thrombotic events - May increase risk of fatal GI events
95
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Tramadol (Ultram, ConZip, Qdolo)
Opioid agonist
\ High addiction/misuse risk
Opioid analgesic REMS
Life threatening respiratory depression can occur
Concomitant use with BZD
96
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Morphine sulfate (Kadian, Morphabond, MS Contin)
Opioid agonist
\ High abuse potential - May lead to dependency and respiratory depression may occur even at accepted dosing - Adverse CV events and death reported on misuse
97
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Hydrocodone + APAP (Norco, Lotab)
Opioid combo + non-narcotic
\ Avoid doses of APAP >4000mg per day (associated with cases of acute liver failure)