Pharmacy Compounding: PEG Troches, PLO Gel, and Topical Preparations
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34 Terms
What is bentonite used for in pharmaceutical preparations?
A suspending agent.
What does PEG stand for?
Polyethylene glycol.
What is a troche?
A solid oral dosage form designed to dissolve slowly in the mouth.
What is Base A in the PEG troches?
The polyethylene glycol troche base.
What is the function of citric acid in PEG troches?
It provides tartness and improves flavor.
What is the function of steviol glycosides or aspartame in PEG troches?
It is a sweetening agent.
What is the function of silica gel in PEG troches?
It helps keep the powders evenly dispersed in the melted base.
What is the function of acacia in PEG troches?
It is a suspending agent
What is the function of Base A in PEG troches?
It forms the troche base.
What technique is used to combine the powders for PEG troches?
Trituration with a mortar and pestle until uniformly mixed.
What does PLO stand for?
Pluronic lecithin organogel.
What are the two major phases of PLO gel?
Lecithin/isopropyl palmitate solution and poloxamer or Pluronic gel.
Why should Pluronic gel remain refrigerated until PLO is prepared?
It stays fluid when cold and is easier to measure and mix; it becomes more viscous as it warms.
Which ingredient in PLO gel increases skin permeability?
Lecithin.
What is lecithin's function in PLO gel?
It is an emulsifier and penetration enhancer that increases skin permeability.
What is the function of isopropyl palmitate in PLO gel?
It is the oil-phase vehicle and solvent.
What is the function of sorbic acid in the lecithin/isopropyl palmitate solution?
It is an antimicrobial preservative.
What is the function of poloxamer F127 or Pluronic F127?
It is the gelling agent
What is the function of potassium sorbate in poloxamer gel?
It is an antimicrobial preservative.
What amounts of the two PLO components were used in lab?
5 mL lecithin/isopropyl palmitate solution and 20 mL poloxamer gel.
What are the active ingredients in the lab's wart remover?
Lactic acid and salicylic acid.
What is the function of lactic acid and salicylic acid in wart remover?
It is a keratolytic that softens and removes thickened wart tissue.
What is Flexible Collodion's function in wart remover?
It is a film-forming vehicle that holds the active ingredients against the wart.
What is the function of pyroxylin in collodion?
It forms a film after the solvents evaporate.
What is the function of castor oil in Flexible Collodion?
It acts as a plasticizer that makes the film flexible.
Which Flexible Collodion ingredients make it flammable?
Ether and Ethanol
What is the purpose of menthol in an insect-bite preparation?
It acts as a counterirritant, antipruritic, and cooling analgesic.
What is one topical use of zinc oxide?
It is used as a skin protectant and astringent.
What is one topical use of starch?
It is used as an absorbent and skin protectant.
What does NF stand for?
National Formulary.
What is the function of sucrose in Syrup NF?
It provides sweetness, viscosity, and preservation at the proper concentration.
What is the function of methylcellulose in Methylcellulose Gel?
It is a gelling agent
Why is methylcellulose initially dispersed in hot water?
To wet and distribute the powder while preventing immediate clumping.
Name two ingredients found in flexible collodion
camphor and ether