TB - tuberculosis

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7 Terms

1
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TB basics

mycobacterium TB is “acid-fast” bacteria

stages:

  • transmission → primary infection → latent TB → active TB

s/s:

  • low grade fever

  • weight loss

  • cough

  • fatigue

  • night sweat

  • hemoptysis

screened with mantoux skin

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RIPE hook

 R = Red (fluids) + Revs up enzymes

I = Injures nerves → give B6 ("INH + B6")

P = Poisons the liver ("P for Pyra-liver")

E = Eyes (Ethambutol)

Three of the four (R, I, P) hit the liver. Check LFT

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RIPE

Rifampin

Isoniazid

Pyrazinamide

Ethambutol

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rifampin

 MOA:

  • Inhibit RNA synthesis

Broad spectrum

AE:

  • Red-orange body fluid

  • Hepatotoxicity

  • Renal failure

  • CYP450-inducer


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isoniazid

MOA:

  • Inhibits cell wall formation

Selective for mycobacteria

AE:

  • Hepatotoxicity → jaundice

  • Peripheral neuropathy

Teaching:

  • Take pyridoxine → B6

  • LFT


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pyrazinamide

AE:

  • hepatotoxicity

report jaundice


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ethambutol

AE:

  • optic neuritis

report blurred vision or color changes