General Toxicology II

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4 Terms

1
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What is the median lethal dose?

statistically derived single dose of a substance that can be expected to cause death in 50% of the animals tested

2
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What is potency?

range of doses over which a chemical produces increasing responses

3
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What is maximal efficacy?

reflects the limit of the dose-response relationship on the response axis to a certain chemical

4
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What is metabolism or biotransformation?

process whereby chemical reactions transform xenobiotic compounds in the body