Chapter 8: Chromosome Variation

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8 Terms

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Aneuploidy

A variation in individual chromosome number

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Nullisomy

Loss of homologous pair (2N-2)

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Trisomy

Gain of single chromosome (2N+1)

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Monosomy

Loss of single chromosome (2N-1)

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Non-disjunction

Failure of chromosomes to separate during cell division (mitosis/meiosis)

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When/How does Aneuploidy occur?

Due to non-disjunction

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Non-disjunction in Meiosis 1

all aneuploidy: 2 (2N-1) & 2 (2N+1)

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Non-disjunction in Meiosis 2

2 normal, 2 aneuploidy: 1 (2N+1) & 1 (2N-1)