RX523 Pharmacokinetics in Older Adults

How does oral absorption change in older adults?

- Decreased gastric acid secretion

- Delayed gastric emptying

- Decreased GI motility

- Decreased bioavailability for drugs requiring acidic pH

- Increased bioavailability for high ER drugs

- Decreased first-pass metabolism

How does absorption change through other routes in older adults?

- Increased transdermal

- Decreased subcutaneous

- Decreased intramuscular

- Decreased pulmonary

- Decreased ocular

How does distribution change in older adults?

- Decreased lean body mass, decreased Vd for those drugs

- Increased total body fat mass, increased Vd and half-life for those drugs

- Decreased Vd for hydrophilic drugs, decrease dose

- Albumin may decrease

- Increased alpha-1 acid glycoprotein

- Decreased P-glycoprotein

How does metabolism change in older adults?

- Decreased hepatic blood flow

- Decreased metabolism of high ER drugs, decrease dose

How does renal excretion change in older adults?

- Decreased GFR and tubular secretion

- Function declines with age

- Cockcroft-Gault overestimates function

Which statement accurately describes a commonly occurring physiological characteristic that may impact drug distribution or protein binding in an older adult?

Decreased muscle mass

Match the route of drug administration with the predicted absorption effect on bioavailability for an older adult patient.

Intramuscular

Decreased

Match the route of drug administration with the predicted absorption effect on bioavailability for an older adult patient.

Subcutaneous

Decreased

Match the route of drug administration with the predicted absorption effect on bioavailability for an older adult patient.

Transdermal

Increased

Which statement accurately describes a commonly occurring physiological characteristic that may impact drug metabolism in an older adult?

Reduced hepatic clearance for high ER drugs

Which statement accurately describes a commonly occurring physiological characteristic that may impact drug excretion in an older adult?

Increased estimated CrCl with reduced Scr with reduced muscle mass

Which statement accurately describes a commonly occurring physiological characteristic that may impact oral drug absorption in an older adult?

Decreased GI motility