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intracellular accumulations
can be reversible or cause cell death


intracellular accumulations: lipidosis

intracellular accumulations: lipidosis (gross)
• Enlarged, normally diffuse, pale yellow, friable, greasy texture
• Severely affected = float in water

intracellular accumulations: lipidosis (histo)
• Cytoplasm is enlarged → Optically empty vacuoles
• Displace nucleus to periphery


intracellular accumulations: proteins (histo)
• Rounded, eosinophilic droplets, vacuoles/aggregates
• ER = distended → Large eosinophilic inclusions (Russell bodies)


more pics lawl


Intracellular accumulations: Glycogen

Intracellular accumulations: Glycogen (histo)
• Clear vacuoles within the cytoplasm with feathery appearance
• PAS +


Intracellular accumulations: Pigments
Intracellular accumulations: Carbon

intracellular accumulations: lipofuscin


intracellular accumulations: melanin
Intracellular accumulations: Hemosiderin/Hemosiderosis


Intracellular accumulations: Hemosiderin/Hemosiderosis
pathologic calcifications




cellular aging
where you going kids
