Pharmacology Week 8

What are Alkylating Agents

They bind to damage DNA during cell division, which stops cell replication

What are some exmaples of Alkylating Agent

Suffix: -ine, -ide, -in, -an, and Chlorambucil

Which part of the Chemoman does an Alkylating Agent affect

C - nephrotoxicity (Kidney) and ototoxicity (Ear)

What are Antimetabolites

Either inhibit enzyme production needed for DNA or RNA synthesis or replace normal nucleotides in DNA or RNA production

What are examples of Antimetabolites

Suffix: -bine, fluorouracil, hydroxyurea, mercaptopurine, thioguanine

Which part of the Chemoman does an Antimetabolites

MF - myelosuppression (Bones)

What are Topoisomerase Inhibitors

Interfere with DNA repair function of topoisomerases and disrupt the cell replication process

What are examples of Topoisomerase Inhibitors

Sufix: -rubicin, etoposide

What are the two drug classes within Topoisomerase Inhibitors

Anthracyclines and Campothecins

What are the drugs under Anthacyclines

Daunorubicin and Mitoxantrone

What are the Campothecins

Irinotecan, irinotecan, liposomal, topotecan

What is the color of metotrexate

Yellow

What are Antimicrotubule Agents

Interfere with the formation and function of microtubules, ultimately preventing cell growth and function

What are examples of Antimicrotubule Agents

Suffix: -xel, -stine, albumin bound, eribulin, liposomal, vinorelbine

Which part of the Chemoman does an

V - peripheral neuropathy (Arms and Legs)

What are the Two drug classes under Chemotherapy Drugs

Bleomycin and Asparaginase

What are Bleomycin

Causes cuts or breaks in DNA strands, preventing cell proliferation

What are Asparaginase

Breaks down asparagine, an amino acid required by leukemia cells and
which they are not able to make

What are the risk of taking Asparaginase

Liver Toxicity

Which part of the Chemoman does an Bleomycine

B - Pulmonary Fibrosis (Lungs)

What are Antiestrogens

Either block estrogen receptors or prevent synthesis of estrogen in postmenopausal individuals

What is example Antiestrogens

Tamosxifen, anastrozole, letrozole, exememstane

What are the side effects of Antiestrogens

Hot flashes, mood swings, depression, increased risk for blood clots and
endometrial cancer.

What are Antiandrogen

Either block the activity of testosterone at the receptor level or interfere with its production

What are example of Antiandrigen

Suffix: -tamide and abriraterone

What are Luteinizing Hormone-Releasing Hormone (LHRH) Agonists

Through the negative feedback loop, stop the production of sex hormones

What are examples of Luteinizing Hormone-Releasing Hormone (LHRH) Agonists

Leuprolide (Lupron) and Goserelin (Zoladex)

What are Cyclin-Dependent Kinase (CDK 4/6) Inhibitors

Interrupt signals that stimulate the proliferation of malignant cells

What are examples of Cyclin-Dependent Kinase (CDK 4/6) Inhibitors

Suffix: -lib

What are Agiogenesis Inhibitors

Prevent tumor cells from building blood vessels that would supply the tumor with vital nutrients

What are examples of Agiogenesis Inhibitors

Suffix: -domide, -nib, -mab and zivafivercept

What are Monoclonal Antibodies

Directed against a specific marker or antigen on a target cell

What are examples of Monoclonal Antibodies

Suffix: -mab, -nib, emtansine and deruxtecan

What are Signal Transduction Inhibitors

Blocks communication and intracellular functions related to tumor growth and
proliferation

What are examples of Signal Transduction Inhibitors

Sufiix: -tinib

What are Bruton’s Tyrosine Kinase (BTK) Inhibitors

Block the enzyme BTK which blocks B cell receptor signaling in certain cancer
cells and triggers cell death

What are examples Bruton’s Tyrosine Kinase (BTK) Inhibitors

Acalabrutinib, Ibrutinib, Zanubrutinib

What are PI3K/AKT/mTOR Pathway Agents

Alteration of pathway that regulates cell survival, proliferation, and growth and can lead to resistance

What are examples of PI3K/AKT/mTOR Pathway Agents

Alpelisib, Idelalisib

What are Immunotherapy for?

To help the body find and attack cancer cells that could evade the body’s
immune system.

What is Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4)