Week 10 - Cancer Causes + Types

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Last updated 6:33 AM on 10/9/26
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14 Terms

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Tumour Suppressor

Protective genes that slow cell division + allow DNA repair + tell cells to die

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Oncogenes

Accelerate cell division

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3 Genes Involved in Cancer

Tumour suppressor

Oncogenes

Mismatch repair

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Somatic Mutations AKA

Sporadic

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Germline Mutations AKA

Hereditary

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Knudson’s Hypothesis

Two hit

Both alleles of tumour suppressor gene mutated

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Knudson’s Multistep Model - Process

Retinoblastomas

Sporadic - 1st & 2nd introduced

Hereditary - 1st inherited & 2nd introduced (earlier onset)

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Internal Causes

Faulty DNA repair

Inherited mutations

Epigenetic mutations

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External Causes

Chemical mutagens

Radiation

Infection

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5 Types

Carcinoma

Sarcoma

Leukaemia

Myeloma

Lymphoma

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Carcinoma

Epithelium

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Sarcoma

CT

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Leukaemia

Bone marrow

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Myeloma

Plasma cells in bone marrow