Explain the underlying mechanisms for each category of clotting disorder (e.g. thrombocytosis, increased platelet activity, conditions that increase coagulation)

thrombocytosis

too many platelets causing abnormal clot formation when not needed 

Primary essential thrombocytosis

bone marrow problem causing excessive platelet production 

secondary/reactive thrombocytosis:

 occurs bc of another condition like cancer, inflammation or infection 

increased platelet activity

 platelets are too active/sticky aggregating more easily platelet count is normal

what causes increased platelet activity

endothelial injury or sluggish blood flow

what are things that increase the risk of increased platelet activity

smoking, hyerlipidemia, and diabeties

increased coagulation acvitivy

bloods clotting system is too active so person forms abnormal clots 

bad blood flow stasis =

blood isn't moving normally moving very slow; immobility can cause the blood to pool increasing risk of DVT

DVT

 deep vein thrombosis → blood clot forms in deep veins this can break off and travel through the bloodstream to the lungs

what does DVT cause

pulmonary embolism

what else causes the blood flow to become stagnante in parts of the atria

atrial fibrillation

atrial fibrilation

can cause bad blood flow stasis increasing clot risk

increased coagulation factors include

estrogen, smoking and cancer

antophospholipid syndrome

autoimmune disorder that makes the blood more likely to form abnormal clots