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PTHrP and hypercalcemia of malignancy
Squamous cell carcinoma
All other paraneoplastic besides PTHrP/hyperCa
Small cell
Non-smokers, peripheral location
Adenocarcinoma
Smokers, central location, metastatic at presentation usually
Small cell
Smokers, centrally located, can cavitate
Squamous cell
Large, polygonal cells with pale cytoplasm
Large cell
NLST mortality reduction
20% reduction from lung cancer specific, 7% reduction overall mortality