intrinsic/extrinsic factors in post natal neural development

behavioral tetatology

study of how maternal environment influences nervous system development in the fetus;

transgenic model

an animal (usually a mouse) with the artificial introduction or removal of a gene

knockout (KO)

gene has been selectively inactivated

conditional KO

Expression may be targeted to certain cell types in the body, or its KO/ transgene is present in the DNA but it is not active until a desired time during development

epigenetics

Changes how genes are expressed, produced by chemical modification of DNA or the proteins it wraps around, without any changes to the DNA sequence itself

DNA methylation

chemical modification of parts of the genome

histone modification

alteration of histone proteins

How ASD happens

A bnormal development of interneurons in the cerebral cortex

jow ADHD happens

differences on prefrontal cortex, DA meslimbic patheay