chapter 1 immunology - Integration + Active vs. Passive Immunity

Do innate and adaptive immunity work independently?

No; they continuously interact.

What does innate immunity do to adaptive immunity?

Shapes and directs the adaptive response.

How many signals are required to activate B and T cells according to this chapter?

At least two.

Why does adaptive immunity require multiple signals?

To help regulate whether an immune response is appropriate.

Can adaptive immunity use innate immune effectors?

Yes.

What is ADCC?

Antibody-dependent cell-mediated cytotoxicity.

Which innate cell can perform ADCC?

Natural killer (NK) cells.

What is ADCP?

Antibody-dependent cellular phagocytosis.

What is CDC?

Complement-dependent cytotoxicity.

What is active immunity?

Protection produced by one's own immune system.

What are examples of active immunity?

Vaccination and infection.

What is passive immunity?

Transfer of immune protection between individuals.

What is an example of natural passive immunity?

Immunity transferred from mother to fetus or newborn.

What is an example of artificial passive immunity?

Treatment with antiserum or immune serum.

What four core components occur in both arms of the immune response?

Recognition, signal transduction, response/effectors, and regulation.

What does innate immunity use for recognition?

PRRs recognizing PAMPs and DAMPs.

What does adaptive immunity use for recognition?

BCRs and TCRs.

What is a major B-cell effector?

Antibody.

What is a major T-cell effector?

Antigen-specific T cells.