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Thiamin Structure:
Pyrimidine ring +
thiazole ring
Thiamin: Active Coenzyme
Thiamin
pyrophosphate
(TPP)
Thiamin: RDA and UL
Men: 1.2 mg/day
Women: 1.1 mg/day
Pregnancy / Lactation: 1.4 mg/day
UL: none established
Thiamin: Rich Food Sources
Enriched/fortified grains, pork, whole grains, sunflower seeds, black beans
Thiamin: Metabolic Functions
impairs ATP generation and carbohydrate oxidation
Thiamin Deficiency Symptoms
(wet: edema/heart failure; dry: muscle wasting/neuropathy), Wernicke-Korsakoff syndrome.
Thiamin At risk:
Alcohol dependency, bariatric surgery patients, chronic malnutrition.
Thiamin Deficiency Symptoms
Beriberi (wet: edema/heart failure; dry: muscle wasting/neuropathy), Wernicke-Korsakoff syndrome.
Thiamin Assessment:
Erythrocyte transketolase activity or thiamin diphosphate in whole blood.