FINALS: Intro to Malignancies (4)

Hyperuricemia

Which additional laboratory abnormality may occur in CML?

15%

A total leukocyte count greater than 300,000/µL is reported in approximately what proportion of CML cases in the lecture?

Splenomegaly

Which organ enlargement is commonly associated with CML?

Accelerated phase

During CML progression, which phase may occur before blast transformation?

Severe anemia and thrombocytopenia

Which finding is associated with CML blast crisis?

Trisomy 8

Which chromosome abnormality may accumulate during CML progression?

• Isochromosome 17

• Loss of Y chromosome

• Trisomy 19

Which additional chromosome abnormality may be seen in CML progression?

Lacks the Philadelphia chromosome and shows mainly neutrophilic granulocytes

Chronic neutrophilic leukemia differs from CML because it:

10%

In chronic neutrophilic leukemia, fewer than what percentage of blood neutrophils are immature?

4 years

Juvenile myelomonocytic leukemia typically occurs in children younger than:

RAS/MAPK pathway

Juvenile myelomonocytic leukemia is associated with mutations involving which pathway?

Imatinib mesylate

Which treatment is a tyrosine kinase inhibitor used in CML?

Bone marrow or stem cell transplantation

Which treatment may be curative for selected CML patients?

Suppress the Philadelphia chromosome clone

Interferon-alpha treatment in CML may:

Drug resistance

A concern with imatinib treatment is the development of:

Most common myeloproliferative neoplasm

Polycythemia vera (PV) is described in the lecture as the:

95% or more

Approximately what percentage of PV cases are positive for a JAK2 mutation?

Erythropoietin (EPO)

In PV, erythroid cells proliferate independently of:

Panmyelosis

The increased production of erythroid, myeloid, and megakaryocytic lineages in PV is called:

Plethora

Which is a hallmark clinical feature of PV?

Increased hemoglobin, hematocrit, and RBC count

Which laboratory result is expected in PV?

Decreased

Serum EPO levels in PV are typically:

JAK2 V617F or JAK2 exon 12

Which mutation is associated with PV?

Hypercellularity with trilineage growth

Which bone marrow feature is part of the WHO major criteria for PV?

Elevated hemoglobin or hematocrit

Which is a major criterion for PV?