DEENT Exam 4 Sikazwe

ethanolamine structure

diphenhydramine is a

1st gen antihistamine

diphenhydramine has what structure

ethanolamine

ethanolamines are structures in what type of drugs

1st gen antihistamines

dimenhydrinate has what structure

ethanolamine

dimenhydrinate is a

1st gen antihistamine

doxylamine succinate is a

1st gen antihistamine

doxylamine succinate has what structure

ethanolamine

carbinoxamine is a

1st gen antihistamine

carbinoxamine has what structure

ethanolamine

clemastine fumarate is a

1st gen antihistamine

clemastine fumarate has what structure

ethanolamine

1st gen antihistamines that are ethanolamine structures undergo what metabolisms

N-dealkylation

MAO

ALDH

ethylenediamines structure

ethylenediamines are structures in what type of drugs

1st gen antihistamines

tripelennamine has what structure

ethylenediamine

tripelennamine is a

1st gen antihistamine

pyrilamine malate is a

1st gen antihistamine

pyrilamine malate has what structure

ethylenediamine

antazoline is a

1st gen antihistmaine

antazoline has what structure

ethylenediamine

1st gen antihistamines that have ethylenediamine structures undergo what biotransformations

N-dealkylation

MAO

ALDH

piperazine structure

piperazine is in what class of drugs

1st gen antihistamines

cyclizine HCl is a

1st gen antihistamine

cyclizine HCl has what structure

piperazine

chlorcyclizine HCl is a

1st gen antihistamine

chlorcyclizine HCl has what structure

piperazine

meclizine HCl is a

1st gen antihistamine

meclizine HCl has what structure

piperazine

hydroxyzine is a

1st gen antihistamine

hydroxyzine has what structure

piperazine

1st gen antihistamines that have piperazine structures undergo what biometabolisms

N-dealkylation

FMO

propylamine structure

propylamines are in what type of drugs

1st gen antihistamines

pheniramine maleate is a

1st gen antihistamine

pheniramine maleate has what structure

propylamine

brompheniramine maleate is a

1st gen antihistamine

brompheniramine maleate has what structure

propylamine

dexbrompheniramine maleate is a

1st gen antihistamine

dexbrompheniramine maleate has what structure

propylamine

chlorpheniramine maleate is a

1st gen antihistamine

chlorpheniramine maleate has what structure

propylamine

dexchlorpheniramine maleate is a

1st gen antihistamine

dexchlorpheniramine maleate has what structure

propylamine

triprolidine HCl is a

1st gen antihistamine

triprolidine HCl has what structure

propylamine

1st gen antihistamines with propylamine structures undergo what metabolisms

N-dealkylations

MAO

ALDH

AA (amino acid conjugation)

tricyclic structure

tricyclics are in what types of drugs

1st gen antihistamines

azatadine maleate is a

1st gen antihistamine

azatadine maleate has what structure

tricyclic

cyproheptadine HCl is a

1st gen antihistamine

cyproheptadine HCl has what structure

tricyclic

phenindamine tartrate is a

1st gen antihistamine

phenindamine tartrate has what structure

tricyclic

olopatadine HCl is a

1st gen antihistamine

olopatadine HCl has what structure

tricyclic

promethazine HCl is a

1st gen antihistamine

promethazine HCl has what structure

tricyclic

1st gen antihistamines with tricyclic structures undergo what biotransformations

N-dealkylations

piperidine structure

what type of drugs have piperidine structure

2nd gen antihistamines

fexofenadine is a

2nd gen antihistamine

fexofenadine has what structure

piperidine

which 2nd gen antihistamines have tricyclic structure

loratadine and desloratadine

loratadine is a

2nd gen antihistamine

desloratadine is a

2nd gen antihistamine

which 2nd gen antihistamines have piperazine structure

cetirizine and levocetirizine

cetirizine is a

2nd gen antihistamine

levocetirizine is a

2nd gen antihistamine

which 2nd gen antihistamines have multicyclic structures

acrivastine

levocabastine

emadastine

acrivastine is a

2nd gen antihistamine

levocabastine is a

2nd gen antihistamine

emadastine is a

2nd gen antihistamine

acrivastine has how many rings

3

levocabastine has how many rings

4

emedastine has how many rings

3

SAR for antihistamines:

terminal tertiary amine

aromatic groups

alkyl/alkene linjer

R groups on N

morphine is a

opioid antitussive

codeine is a

opioid antitussive

hydrocodone is a

opioid antitussive

dextromethorphan is a

opioid antitussive

benzonatate is a

nonopioid antitussive

chlophedianol is a

nonopioid antitussive

benzocaine is a

local anesthetic

lidocaine is a

local anesthetic

dyclonine is a

local anesthetic

phenol is a

local anesthetic

levmetamfetamine is a

inhaled decongestant

propylhexedrine is a

inhaled decongestant

phenylephrine is a

oral decongestant

pseudoephedrine is a

oral decongestant

decongestants have what structure

phenethylamines

what are the 3 categories of antivirals for cold/flu

adamantanes

neursminidase inhibitors

dibenzothiepines

which drugs are adamantanes

amantadine

rimantidine

which drugs are neuraminidase inhibitors

oseltamivir

zanamivir

peramivir

which drugs are dibenzothiepines

xofluza