Staphylococcus aureus Characteristics

Which is the only coagulase postive staph?

Staphylococcus AUERUS

What are the 6 virulence factors associated with Staphylococcus aureus?

1. Enterotoxin

2. Protein A

3. Cytolytic toxins

4. Exfoliative toxin

5. Enzymes

6. TSST-1

What are ENTEROtoxins associated with?

FOOD POISONING

Which 3 enterotoxins specifically cause food poisoning?

BAD for your stomach toxins

What does Protein A of Staph aureus do?

Involved in REDUCING OPSONIZATION

binding to the IgG Fc region

What are the 3 significant Cytolytic toxins of Staph aureus?

1. alpha

2. beta

3. gamma

Which cytolytic toxin is associated with neutrophil damage (PVL)?

Gamma cytolytic toxin

Which cytolytic toxin is associated with RBC DAMAGE

Beta cytolytic toxin

Think how Beta hemolysis causes COMPLETE RBC LYSIS

Which cytolytic toxin is associated with TISSUE damage?

alpha cytolytic toxin

Which virulence factor of Staphylococcus aureus is associated with Epidermal damage/Scalding Skin Syndrome/Bullous impetigo?

Exfoliative Toxin

Who is typically affected by Bullous impetigo?

INFANTS + children

Caused by the Exfoliative toxin (A or B)

Which ENZYME (Virulence Factor) of Staphylococcus aureus helps it to spread throughout connective tissue?

Hyaluronidase

PPB2 in Staphylococcus aureus is associated with which kind of Antimicrobial resistance?

METHICILLIN resistance

Which S. auerus enzyme is associated with destruction of beta lactam antibiotic activity?

Beta-lactamases

What is TSST of Staph. aureus?

Toxic Shock Syndrome Toxin

A SUPERANTIGEN

What does TSST cause the MASSIVE release of?

CYTOKINES causing severe fever,rash,shaking,SHOCK