Extra drugs he added (block 1)

buprenorphine

partial u-opioid receptor agonist, high receptor affinity but lower efficacy than full opioid agonists

metacholine

muscarinic receptor agonist, mimics Ach at muscarinic receptors including on bronchial SM, used to diagnose asthma

botulism toxin

prevents pre-synaptic Ach release by disrupting vesicle fusion, reduces cholinergic transmission

prazosin

competitive a-1 adrenergic antagonist, reduces a-1 mediated SM contraction, causes vasodilation and relaxation of urinary outflow SM

dobutamine

predominantly B-1 adrenergic agonist, increases cardiac contractility and CO

propranolol

nonselective B-1/B-2 adrenergic antagonist, blocks sympathetic B receptor effects, including B-1 mediated cardiac stimulation

yohimbine

a-2 adrenergic antagonist that blocks presynaptic a-2 autoreceptors, removes negative feedback on NE release -> increases NE signaling