Lecture 6

Respiratory

moderate level, moderate response time

metabolic acidosis → resp. alkalosis

decrease HCO3- fix/comp. decrease CO2

-

metabolic alkalosis fix/comp. respiratory acidosis

Renal compensation (urinary)

Slowest/ most powerful

daily metabolism - body is making acids

but blood pH is alkaline

ex. carbonic acid → volatite acids( CO2 can be exhaled + decrease concentration of volatite acids)

ex. Lactic acids, uric acid, ketoacids → non-volatile acids (resp. system will not affect the concentrations)

Kidneys

-reabsorbs HCO3- + production of new HCO3-

-secretes H+

Where did most HCO3- reabsorption + H+ secretion take place?

PCT: overall reabsorbed 80-90% HCO3- + secreted 80-90% of H+

PCT and CT: Cell population-

Principal cells (Na+, CL-, K+)

Intercalated cells ( can be adjusted (400x)

-reabsorbed 10-20% HCO3-

-secrete 10-20% H+

Respiratory acidosis

increase CO2 → increase H+ → decrease pH

fix/comp.:

metabolic alkalosis: intercalated cells will increase HCO3 prod. and reabsorption

increase H+ secretion

Respiratory Alkalosis

low carbon dioxide

fix/comp:

metabolic acidosis

kidneys stimulate intercalated cells → decrease HCO3- reabsorption and production

decrease H+ secretion

pH derangements

Summary nephron

Intercalated cells