Pharm

CYP11B2

makes aldosterone and is made in the zone glomerulosa.

CYP11B1

makes cortisol.

CYP17

makes cortisol and DHEA.

Transcription factor

binds and block inflammatory so there is suppressed synthesis of pro inflammatory proteins (COX2)

Exenatide

GLP-1 receptor agonist. Blocks glucagon release and stimulates insulin release.

Pramlintide

amylin targeted to decrease appetite.

Octreotide

mimics somatostatin, blocks growth hormones, glycogen and insulin.

Metformin

inhibits glucose production in the liver by activation of AMPK.

Glut 2

releases insulin in the blood when there is high glucose. works in the liver, kidney, gut

Glut 4

muscle, adipose

Tamoxifen

partial against for estrogen in breast cancer treatment.

Mifepristone

agonist of progesterone receptor. morning after pill

H2RAs (Cimetidine, Famotidine, Nizatidine)

reduce the frequency and severity of heartburn symptoms.

PPIs (Omeprazole, Lansoprazole, Rabeprazole)

most potent inhibitors of gastric acid secretion. binds to the proton pump in parietal cells.

Cytoprotective Therapy (Misoprostol, Sucralfate, Bismuth)

enhances mucosal protection mechanisms, preventing mucosal injury, reducing inflammation, and healing existing ulcers.

Ranitidine

H2RAs adverse effects. cancer-causing substance NMDA found as contaminant in these products. FDA immediate market withdrawal on April 1, 2020.

Carbidopa

first step to treating Parkinson's disease. helps breakdown the metabolism of L-dopa to DA so L-dopa can cross the BBB to create tyrosine and more free floating DA. inhibits DDC.
-side effects: hypotension, nausea, loss of appetite, urine disoloration

Entacapone

inhibits COMT. used when the levels of dopamine are closer to the therapeutic window.
-Side effects: Hypotension, loss of appetite, urine disocoloration

Talcapone

inhibits COMT. used when the DA levels are farther from the therapeutic window and Entacapone is not working.
-Side effects: Hypotension, loss of appetite, urine discoloration

Selegiline and Rasagiline

blocks MAO-B from metabolizing DA. allows for more free floating DA.
side effects: insomnia, nausea

Talcapone (after DAT)

blocks COMT from metabolizing DA. allows for more free floating DA.
Side effects: Insomnia, nausea

Bromocriptine, Ropinirole, Pramipexole, Rotigotine, Apomorphine

DA agonists. first 4 - D2. last - D1 and D2. when phase 1 fails, phase 2 begins.
side effects: nausea, BP, waking sleepiness

Benztropine, Biperiden, Trihexyphenidyl

mAChr blockers. target tremors. when phase 2 fails, phase 3 begins.
Side effects: dry mouth, urine retention, constiapation

Cocaine

blocks the DAT and NET from DA going through. blocked on the outside

Amphetamine

goes through channel, competes with neurotransmitters and pushed out of DAT and NET to not be reuptaked.

Caffeine

blocks the A1 and A2A receptors.

Clozapine and Olanzapine

blocks the 5HT2C receptors. 2nd generation.
side effects: increase glucose lipids

Clozapine, Olanzapine, Quetiapine

blocks the histamine receptors. 2nd generation
Side effects: weight gain, wake sleepy

Clozapine, Risperidone

highest affinity for D2. blocks alpha 1 receptors. 2nd generation
Side effects: dry mouth, constipation, urine retention

chloropromazine

low potency for 1st generation. need a higher dose.

Haloperidol, Fluphenazine, Prochloroperazine, Trifluoperazine

high potency for 1st generation. need a lower dose.

Disulfiram

ALDH inhibitor. used to overcome drinking disorders.

Fomepizole

ALDH inhibitor. used as an antidote in methanol or ethylene glycol poisoning.

Vismodegib

systemic treatment with hedgehog inhibitors when a person has advanced or metastatic BCC.

PD-1, PD-L1, CTLA-4

immune therapies for melanoma

Vemurafenib, Dabrafenib

braf inhibitors for melanoma

Acitretin

retinoid metabolite for psoriasis

Apremilast

reduces inflammation for psoriasis

Debrisoquine

sympatholytic antihypertensive drug.

Cyp2D6

enzyme in body that determines how fast or slow a person may metabolize a drug based on their genetics.