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Native conformation
polypeptide chain folds into a single stable shape
Biological function (of a protein) depends completely on:
Native conformation
2 key factors contribute to protein structure:
Allowable bond rotation / Weak IMF
Why is Cis less favourable than trans conformation?
due to steric interference of a-carbon side chains
Parallel B sheets
strands run in same N to C terminal direction
Antiparallel B sheets
strands run in opposite N to C terminal directions