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d. nociceptors
pain receptors in the body are called ______________:
a. Meissner's corpuscles
b. Krause's end bulbs
c. Pacinian corpuscles
d. nociceptors
a. substance P
which of the following facilitates transmission of sensations of pain?
a. substance P
b. enkephalin
c. dynorphin
d. serotonin
a. large-diameter fibers
which of the following is/are characteristics of AB fibers?
a. large-diameter fibers
b. slow conduction velocities
c. transmission of brief, localized pain
d. all of the above
b. AB
TENS results in stimulation of the enkephalin interneurons in the dorsal horn via the depolarization of _____________ primary afferent nerve fibers.
a. Aa
b. AB
c. AS
d. C
a. hypothalamus
second-order afferent nerves terminate in all of the following regions except the ____________.
a. hypothalamus
b. thalamus
c. reticular formation
d. periaqueductal gray region of the midbrain
c. both a and b
which of the following affects pain perception?
a. clinical depression
b. past pain experiences
c. both a and b
d. neither a nor b
false
t/f: afferent nerve fibers conduct impulses from the brain to peripheral sites
true
t/f: enkephalins inhibit synaptic transmission in the dorsal horn
false
t/f: electrons tend to flow from areas of low concentration to areas of high concentration
true
t/f: insulators resist current flow
true
t/f: the greater the voltage, the greater the amplitude is
true
t/f: the cathode is the negatively charged electrode in a DC system
b. electron
a particle of matter with very little mass and a negative charge is a(n):
a. ion
b. electron
c. neutron
d. proton
c. volt
what is the name of the unit measuring the force necessary to produce electron movement?
a. ampere
b. coulomb
c. volt
d. watt
a. alternating
in ______________ current, electron flow constantly changes direction
a. alternating
b. direct
c. pulsatile
d. galvanic
b. ramping
when the current increases gradually to a maximal amplitude, it is known as:
a. burst
b. ramping
c. modulation
d. galvanic
d. series
in ____________ circuits, electrons have only one path to follow
a. galvanic
b. parallel
c. resistor
d. series
d. all of the above
physiological responses to electrical current include:
a. thermal
b. chemical
c. physiologic
d. all of the above
b. increase, further apart
to _____________ current density in deeper tissue, the electrodes must be placed ____________
a. increase, closer
b. increase, further apart
c. decrease, closer
d. decrease, further apart
c. opiate pain control theory
electrical stimulation may release enkephalin and endorphin to cause pain relief. what is the name of this pain control method?
a. gate control theory
b. central biasing theory
c. opiate pain control theory
d. placebo effects
a. destructive interference
two currents combine and the amplitude decreases. this is called:
a. destructive interference
b. constructive interference
c. heterodyne current
d. beat current
d. Russian
which of the following currents is a pulsatile biphasic wave, generated in bursts, designed to create muscle contraction?
a. LIS
b. iontophoresis
c. IFC
d. Russian
d. medical galvanism
increased blood flow between electrodes is an effect of which of the following?
a. IFC
b. function electrical stimulation
c. LIS
d. medical galvanism
pain is a multiple system output that is activated by an individual’s specific neural signature, which is activated whenever a person perceives a threat
what is the modern pain definition
an unpleasant sensory and emotional experience associated with or resembling actual or potential tissue damage
what is the old pain definition
acute pain
pain of sudden onset
chronic pain
pain lasting for more than 6 months and may see as low as 3 months
referred pain
pain that is perceived to be in an area that seems to have little relation to the existing pathology
radiating pain
pain caused by irritating nerve roots and extending distally (ex. intervertebral disc herniation)
deep somatic pain
pain associated with a segment of bone innervated by a spinal segment that is a pain (ex. deeper ache like “bone pain”)
nociceptive pain
pain from a normal process that results in noxious stimuli being perceived as painful; the normal physical response to actual or threatened tissue damage to the body
numeric pain rating scale (NPRS)
most common acute pain rating scale, rate on a scale from 1-10
neuropathic pain
pain from damage to neurons of either the peripheral or central nervous system
nociplastic (chronic or central pain)
chronic pain caused by altered nervous system function rather than clear tissue damage or nerve injury
A alpha
type of first order neuron that is proprioceptive and large/fast
A beta
type of first order neuron that is cutaneous and large/fast
A delta
type of first order neuron that is mechano/thermo/nociceptor and carries “fast pain”; is small mylenated/slower
C
type of first order neuron that is mechano/thermo and carries “slow pain”; is small unmylenated/slow
first order/primary afferents
transmit impulses from the sensory receptor to the dorsal horn of the spinal cord
wide dynamic range or nociceptive specific (pain)
what are second order neurons classified as
wide dynamic range
second order afferents that receive input from A beta, A delta, and C fibers
nociceptive specific
second order afferents that respond exclusively to noxious stimulation
A delta and C fibers
what do nociceptice specific second order afferent neurons receive input from
third order neurons
all neurons synapse with what to carry information to various brain centers where the input is integrated, interpreted and acted upon
thalamas to different parts of the brain like the somatosensory cortex
where do the third order neurons typically run
neurotransitters or non-true neurotransmitters that can facilitate or inhibit synaptic activity related to pain
for information to pass between neurons, what must be released that enters the synaptic cleft, and attaches to a receptor site on the next neuron
serotonin
non true neurotransmitter that is active in descending pathways
norepinephrine
non true neurotransmitter that inhibits pain transmission between 1st and 2nd order neurons
substance P
non true neurotransmitter that comes from small-diameter primary afferent neurons in the dorsal portion of spinal cord
enkephalin
non true neurotransmitter that is the opiod active in descending pathways
B-endorphin and dynorphin
what is the opiod endogenous to the CNS
nociceptive neuron
peripheral pain receptor that transmits pain signals
lowers the nerve’s threshold to noxious stimuli
when a cell is injured, what does the release of substance P, prostaglandins, and leukotrines cause that is also known as primary hyperalgesia
secondary hyperalgesia
what is it called when the chemicals spread to increase the size of the pain area to cause hypersensitivity
receptors located in skin
where do A delta fibers originate from to transmit “fast pain”
superficial tissue (skin) and deeper (ligaments and muscle)
where do C fibers originate from to transmit “slow pain”
lateral spinothalamic tract
what is the primary pathway that 2nd order neurons ascend to higher brain centers
gate control theory
stimulation from ascending A beta afferents results in blocking impulses at the spinal cord level of pain messages carried along A delta and C afferent fibers
substantia gelatinosa
what does the gate control theory stimulate at the dorsal horn of the spinal cord
descending mechanisms
stimulation of descending pathways in the dorsolateral tract of the spinal cord which results in a blocking of the impulses carried along the A delta and C afferent fibers; closes gait from the top
release of substance P from A delta and C fibers
what does the activation of enkephalin interneuron synapses by serotonin suppress the release of during descending pain control mechanisms
release of endogenous opioids
the prolonged stimulation of A delta and C afferent fibers causing the release of endogenous opiods (B-endorphin), resulting in a prolonged activation of descending analgesic pathways
beta endorphin
what is the endogenous opioid that is released from the hypothalamus
dynorphin
what is the endogenous opioid that is released from the periaqueductal grey matter within the PAG, medulla, and dorsal horn and may be responsible to noxious mechanical stimulation
overlapping mechanisms
what is pain control the result of so pain relief may result from a combination of all three of these mechanisms
conventional TENS, massage, and analgesic balms
what therapeutic modalities can be used to stimulate the large-diameter A beta fibers afferently through the gate control theory
cold treatments
what therapeutic modality decreases pain fiber transmission velocity
acupressure, deep massage, TENS
what therapeutic modality can be used to stimulate the small-diameter afferent fibers and descending pain control mechanisms (descending control)
low rate TENS
what therapeutic modality can be used to stimulate endogenous opioids through prolonged small diameter fiber stimulation of acupuncture or trigger points (opiate release)
threat
the perception of the threat that determines output, not the tissue damage itself or threat to the tissues
chronic pain/ central sensitization
encompassses altered sensory processing in the brain and malfunction of pain-inhibitory mechanism (constant threat or fear); CNS pain pathways stay active even in absence of peripheral stimulation
education and reducing threat and fear by “turning down the volume”
how do you treat chronic pain/central sensitization
biological, psychological, AND social components
what does pain always encompass
pain
the interpretation of nociceptive signals by the brain
nociception
activity that occurs in the nervous system, peripheral or central, in response to a noxious stimulus
ampere
rate at which electrons flow; volume of electrical current flow
ampere
what is also known as the current
voltage
force resulting from potential difference
voltage
what actually causes the flow or current by pushing it along and is the “electromotive force”
volt
what is the unit of measurement of voltage
resistance
opposition of electron flow; could be conductor or insulator
ohm
what is the unit of measurement of resistance
conductors
have an abundance of free electrons; muscles, nerves, blood
insulators
have very few free electrons; bones and fat
direct current
uninterrupted, unidirectional flow, monophasic, galvanic; dangerous if applied inapropriately
alternating current
continuous flow of electrons that is constantly changing directions, biphasic
pulsatile current
three or more pulses grouped together, polyphasic; could be direct or alternating
sinusoidal, rectangular, square, and triangular
what are the different types of waveforms
pulse
individual waveform
cycle
applies to biphasic currents only and is the “up and down” of one waveform
phase
portion of the pulse that rises in one direction
pulse width/duration
length of time current is flowing in one cycle
phase duration
what is considered the pulse width/duration for monophasic currents
combined phase durations = cycle duration
what is considered the pulse width/duration for biphasic currents
uncomfortable
the wider the pulse width, the more _______________ the stimulation is because it reaches more fibers
pulse rate/frequency
number of cycles or impulses/second; as it gets lower, the more you can identify each pulse (Hz)
cathode (-)
which polarity traditionally gets placed more distally: (cathode or anode)
intensity/amplitude
increasing this can increase the number of nerve fibers depolarized by causing a deeprer reach into the tissue and higher depolarization thresholds
burst modulation
used in pulsatile currents with an interburst interval that can be changed to any length of time
bipolar, unipolar, and quadripolar
what are the common electrode placement types