BMED 5207 termination of translation (exam 3)

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6 Terms

1
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first step of termination of translation

eRF1 binds to the eRF3-GTP

2
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second step of termination of translation

eRF1-eRF1-GTP recognizes stop codon

3
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third step of termination of translation

GTP is hydrolyzed by eRF3

4
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fourth step of termination of translation

GTP hydrolysis of eRF3 causes conformation changes, and this leads to the cleavage of the peptidyl-tRNA bond and the release of the polypeptide

5
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fifth step of termination of translation

a few eIFs and an ATPase are required for the dissociation of ribosomal subunits from the mRNA, for the dissociation of the tRNA from the P site, and for the release of eRF1 and ewRF3

6
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structure of eRF1 protein

similar to a tRNA but is not an RNA