VPTH 122 1st Lab Exam Review (Exercise 1-5)

• Lesions: pin point to pin head hemorrhage in cortical surface, pale

• Morphological Diagnosis: Kidney: Hemorrhage, multifocal, miliary, cortical.

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: pale, radially oriented streaks extending from the cortex toward the medulla

• Morphological Diagnosis: Kidney: Fibrosis, interstitial, multifocal, chronic

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: Numerous multifocal nodules distributed along the surface which varied in size round to irregular, tan to yellow. some appear grey to black, suggestive of hemorrhage or necrosis

• Morphological Diagnosis: Kidney: Nodules, multifocal to coalescing, cortical and capsular

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: spindle cell proliferation expanding the submucosa,

  • neoplastic cells have elongated to tapering nuclei with fine stippled chromatin, inconspicuous nucleoli, and scant, indistinct eosinophilic cytoplasm

• Morphological Diagnosis: Urinary bladder: Suggestive of Spindle cell neoplasm

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: irregular nests, cords, anastomosing trabeculae and variably sized tubules and gland-like structures supported by a prominent fibrocollagenous (desmoplastic) stroma.

  • Neoplastic cells are cuboidal to polygonal with moderate amounts of lightly eosinophilic cytoplasm and distinct cell borders.

• Morphological Diagnosis: Urinary bladder: Invasive urothelial carcinoma

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: extensive interstitial fibrosis, tubules are markedly atrophic, irregular and occasionally dilated,

  • with occasional intraluminal eosinophilic proteinaceous casts

• Morphological Diagnosis: Kidney: Chronic tubulointerstitial nephropathy with marked interstitial fibrosis and tubular atrophy, multifocal glomerulosclerosis and chronic interstitial inflammation

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: marked thickening of transitional epithelial cells lining the epithelium

• Morphological Diagnosis: Urinary bladder: Invasive urothelial carcinoma

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: dark red to reddish-purple and consolidated, with irregular pale areas

• Morphological Diagnosis: Lung: Consolidation, multifocal to coalescing, cranioventral, with pulmonary hemorrhage

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: mucosal surface appears diffusely dark red

• Morphological Diagnosis: Trachea: Hemorrhage, diffuse, mucosal

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: diffusely dark red to reddish-purple, with a heavy, consolidated appearance

• Morphological Diagnosis: Lung: Hemorrhage, diffuse, severe, with multifocal to coalescing areas of consolidation

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: thickening of the interstitium due to infiltration of inflammatory cells predominantly lymphocytes.

  • Eosinophilic materials inside parabronchial lumen/atria.

• Morphological Diagnosis: Lung: Pneumonia, interstitial, multifocal and spreading, moderate with pulmonary edema.

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: multifocal epithelial disruption and sloughing,

  • with irregular accumulation of eosinophilic material and cellular debris along the mucosal surface

• Morphological Diagnosis: Trachea: Tracheitis, necrotizing and degenerative, multifocal, moderate to severe

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: irregular areas of red discoloration and prominent epicardial superficial blood vessels,

  • pale tan to whitish patchy discoloration on the atrium and ventricle

• Morphological Diagnosis: Heart: Fibrosis, multifocal

  • Heart: Epicardial congestion and multifocal hemorrhage.

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: The pericardial sac is filled with a large volume of clear, amber to yellowish-tinted fluid.

  • Epicardial surface is markedly pale, slightly irregular, and partially obscured by thin strands of translucent to white fibrin.

• Morphological Diagnosis: Heart: Hydropericardium

  • Heart: Epicarditis, fibrinous

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: widespread, diffuse loss of normal myocardial architecture.

  • Cardiomyocytes show varying degrees of degeneration and atrophy.

  • Cells are fragmented, poorly defined, and exhibit loss of normal cross-striations with faded, pyknotic, or completely absent nuclei.

• Morphological Diagnosis: Snake Heart: Cardiomyopathy, necrotizing and degenerative, moderate to severe, diffuse, chronic-active

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: diffuse, widespread disruption of the normal cardiac muscle architecture.

  • Cardiomyocytes exhibit profound degeneration, vacuolation, and loss of fiber detail.

  • Individual myofibers are fragmented, poorly defined, and show marked loss of distinct cross-striations.

  • Multiple areas demonstrate fading or absent nuclei (karyolysis/necrosis)

• Morphological Diagnosis: Avian Heart: Cardiomyopathy, necrotizing and degenerative, severe, diffuse, chronic-active

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: diffuse loss of normal myocardial architecture.

  • The cardiomyocytes exhibit advanced degeneration, severe fragmentation, and liquefactive-type necrosis.

  • numerous large, coalescing, irregular clear spaces and round vacuoles.

• Morphological Diagnosis: Heart: Cardiomyopathy, necrotizing and degenerative, severe, diffuse, chronic-active

  • Heart: Myocardial edema and vacuolar degeneration, severe, multifocal to diffuse

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: moderately enlarged with rounded, blunt capsular margins

  • mosaic of dark red to reddish-brown zones intermixed with lighter, pale tan to yellowish zones.

• Morphological Diagnosis: Liver: Chronic passive hepatic congestion.

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: lobes are diffusely enlarged;

  • uniform pale tan-orange to light yellowish-brown discoloration,

  • capsular surface appears smooth, glistening, and somewhat greasy or friable in texture.

• Morphological Diagnosis: Liver: Hepatic steatosis/lipidosis

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: moderately enlarged with slightly rounded, blunt lobar edges;

  • parenchyma is mottled dark red to tan with variable-sized, discrete, round, pale cream-to-white nodules

• Morphological Diagnosis: Liver: Hepatitis, granulomatous

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: loss of hepatocellular architecture,

  • hypereosinophilic cytoplasm,

  • nuclear pyknosis and karyorrhexis, and areas of karyolysis.

  • The necrotic hepatocytes are separated by pale, fragmented cellular debris.

  • The lesions are predominantly centered around central veins, with variable extension into the surrounding hepatic parenchyma.

• Morphological Diagnosis: Hepatocellular necrosis, centrilobular, diffuse, severe

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: hepatocytes show numerous cytoplasmic vacuoles, with affected centrilobular regions exhibiting hypereosinophilic cytoplasm, nuclear pyknosis, karyorrhexis, and karyolysis.

  • Extensive loss of hepatocellular detail and disruption of the hepatic parenchymal architecture are evident in the necrotic areas.

• Morphological Diagnosis: Liver: Hepatocellular necrosis, centrilobular, diffuse, severe, with widespread cytoplasmic vacuolation

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: increased eosinophilia of hepatocytes, loss of nuclear detail, and disruption of hepatic cords in areas adjacent to portal tracts

  • The affected hepatocytes show features consistent with cellular degeneration and necrosis, with extension of the lesions into the surrounding hepatic parenchyma.

  • The remaining hepatocytes exhibit relatively preserved architecture.

• Morphological Diagnosis: Liver: Hepatocellular necrosis, periportal, multifocal to diffuse, severe

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: widespread hepatocellular cytoplasmic vacuolation, characterized by numerous variably sized, optically clear vacuoles within the hepatocyte cytoplasm.

  • The vacuoles are prominent and, in some areas, coalesce, imparting a foamy appearance to the hepatic parenchyma.

  • Scattered hepatocytes exhibit enlarged, rounded, and occasionally hypereosinophilic cytoplasm, with some cells showing nuclear pyknosis or loss of discernible nuclear detail.

  • Multifocal areas of hepatocellular degeneration and possible necrosis are present.

• Morphological Diagnosis: Liver: Hepatocellular vacuolar degeneration, diffuse, severe, with suspected multifocal hepatocellular necrosis.

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: The center of the patch is well-demarcated raw, bright red, with round margin, and appear moist or oozing. Surrounding it is a ring of darker, skin with scabbing, crusting, and matted hair. There is complete hair loss, alopecia, directly over the affected area.

• Morphological Diagnosis: Skin: Dermatitis, necrotizing and ulcerative, localized, moderate to severe with crust, scales

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: Large, multi-lobulated and multinodular exophytic mass arising from the oral mucosa and gingiva, characterized by dark grey to black coloration with a smooth to irregular glistening texture.

• Morphological Diagnosis: Gingiva: Oral Melanoma

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: Elongated, well-demarcated by a dark red ring and highly erythematous lesion within an area of loss of hair suggestive of alopecia. The center is pale pink, exhibiting moist, glistening surface.

• Morphological Diagnosis: Skin: Dermatitis, ulcerative + exudative with crust formation

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: There are round basophilic cells supported by fibrous stroma infiltration displacing surrounding connective tissue

• Morphological Diagnosis: Maxilla/Gingiva: Oral Mast Cell tumor

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: Proliferation of spindle shaped cells

• Morphological Diagnosis: Hindleg: Suggestive of fibrosarcoma

Identify

• Lesions:

• Morphological Diagnosis:

• Lesions: Scattered fibroblasts and cell infiltrate with eosinophilic material displacing connective tissue

• Morphological Diagnosis: Skin: Dermatitis, eosinophilic, multifocal to coalescing, moderate with collagenolysis

Identify

• Lesions:

• Morphological Diagnosis: